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Adrenal lymphoma: presentation, management and prognosis

Laurent, C ; Casasnovas, O ; Martin, L ; Chauchet, A ; Ghesquieres, H ; Aussedat, G ; Fornecker, L M ; Bologna, S ; Borot, S ; Laurent, K ; Bouillet, B ; Verges, B ; Petit, J-M

Journal of Electron Microscopy, 2017-02, Vol.110 (2), p.103-109 [Periódico revisado por pares]

England: Oxford University Press (OUP)

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Título:
Adrenal lymphoma: presentation, management and prognosis
Autor: Laurent, C ; Casasnovas, O ; Martin, L ; Chauchet, A ; Ghesquieres, H ; Aussedat, G ; Fornecker, L M ; Bologna, S ; Borot, S ; Laurent, K ; Bouillet, B ; Verges, B ; Petit, J-M
Assuntos: Adrenal Gland Neoplasms - complications ; Adrenal Gland Neoplasms - diagnosis ; Adrenal Gland Neoplasms - drug therapy ; Adrenal Gland Neoplasms - epidemiology ; Adrenal Insufficiency - epidemiology ; Adrenal Insufficiency - etiology ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Female ; France - epidemiology ; Human health and pathology ; Humans ; Life Sciences ; Lymphoma, Non-Hodgkin - complications ; Lymphoma, Non-Hodgkin - diagnosis ; Lymphoma, Non-Hodgkin - drug therapy ; Lymphoma, Non-Hodgkin - epidemiology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Positron-Emission Tomography ; Prognosis ; Retrospective Studies ; Tomography, X-Ray Computed
É parte de: Journal of Electron Microscopy, 2017-02, Vol.110 (2), p.103-109
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SourceType-Scholarly Journals-1
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Descrição: This study aimed to identify the clinical, radiological and prognostic features of primary adrenal lymphoma (PAL) in order to diagnose the disease more accurately. A retrospective multi-centre study was conducted on the clinical, biological and radiological features as well as the treatment and overall survival outcomes in PAL. Between 1994 and 2014, 28 patients from five regions of eastern France were diagnosed with primary adrenal lymphoma. The revealing symptoms were a worsening general state (77%), weight loss (77%) and abdominal pain (42%). Biological features of PAL were almost omnipresent: increased LDH, β2 microglobulin, CRP or ferritinaemia levels. The PAL was bilateral in 20 cases (71%), adrenal insufficiency was searched for in 11 patients and found in eight (73%). CT scans showed masses of various sizes measuring up to 180 mm. On MRI, the lesions were hypointense in T1 and hyperintense in T2. When done, positron emission tomography with fluorodeoxyglucose (FDG-PET) showed locations not seen on the CT and revealed extra-adrenal locations in 70% of examinations. Adrenalectomy brought no benefit. The overall survival rate was poor (61.9% at 2 years) despite polychemotherapy. The clinical presentation of PAL comprised major general symptoms. Adrenal insufficiency was very common in patients with bilateral involvement but was not systematically tested. PET was an efficient examination to visualize extra-adrenal locations. The preliminary results of MRI to distinguish between PAL and adrenocortical carcinoma should be confirmed. Further studies are needed to establish an optimal strategy for the management of these primary adrenal lymphomas.
Editor: England: Oxford University Press (OUP)
Idioma: Inglês

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Adrenal lymphoma: presentation, management and prognosis

Laurent, C ; Casasnovas, O ; Martin, L ; Chauchet, A ; Ghesquieres, H ; Aussedat, G ; Fornecker, L M ; Bologna, S ; Borot, S ; Laurent, K ; Bouillet, B ; Verges, B ; Petit, J-M

England: Oxford University Press (OUP)

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