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The transcriptional control machinery as well as the cell wall integrity and its regulation are involved in the detoxification of the organic solvent dimethyl sulfoxide in Saccharomyces cerevisiae

Zhang, Lilin ; Liu, Ningning ; Ma, Xiao ; Jiang, Linghuo

FEMS yeast research, 2013-03, Vol.13 (2), p.200-218 [Revista revisada por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
The transcriptional control machinery as well as the cell wall integrity and its regulation are involved in the detoxification of the organic solvent dimethyl sulfoxide in Saccharomyces cerevisiae
Autor: Zhang, Lilin ; Liu, Ningning ; Ma, Xiao ; Jiang, Linghuo
Materias: Biotransformation ; Cell Wall - drug effects ; cell wall integrity ; Cell walls ; Detoxification ; Dimethyl sulfoxide ; Dimethyl Sulfoxide - metabolism ; Dimethyl Sulfoxide - toxicity ; DMSO ; DNA-directed RNA polymerase ; Gene expression ; Gene Expression Regulation, Fungal ; Genomics ; Metabolic Networks and Pathways - genetics ; Mutation ; Protein transport ; RNA polymerase ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - drug effects ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Solvents - metabolism ; Solvents - toxicity ; SWR1 ; Transcription ; Transcription, Genetic ; vacuolar protein sorting ; Yeast
Es parte de: FEMS yeast research, 2013-03, Vol.13 (2), p.200-218
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descripción: Abstract In the present study, we have identified 339 dimethyl sulfoxide (DMSO)-sensitive and nine DMSO-tolerant gene mutations in Saccharomyces cerevisiae through a functional genomics approach. Twelve of these identified DMSO-sensitive mutations are of genes involved in the general control of gene expression mediated by the SWR1 complex and the RNA polymerase II mediator complex, whereas 71 of them are of genes involved in the protein trafficking and vacuolar sorting processes. In addition, twelve of these DMSO-sensitive mutations are of genes involved in the cell wall integrity (CWI) and its regulation. DMSO-tolerant mutations are of genes mainly involved in the metabolism and the gene expression control. Therefore, the transcriptional control machinery, the CWI and its regulation as well as the protein trafficking and sorting process play critical roles in the DMSO detoxification in yeast cells.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglés

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The transcriptional control machinery as well as the cell wall integrity and its regulation are involved in the detoxification of the organic solvent dimethyl sulfoxide in Saccharomyces cerevisiae

Zhang, Lilin ; Liu, Ningning ; Ma, Xiao ; Jiang, Linghuo

Oxford, UK: Blackwell Publishing Ltd

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