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Molecularly Imprinted Polymers for the Determination of Cancer Biomarkers

Pilvenyte, Greta ; Ratautaite, Vilma ; Boguzaite, Raimonda ; Ramanavicius, Arunas ; Viter, Roman ; Ramanavicius, Simonas

International journal of molecular sciences, 2023-02, Vol.24 (4), p.4105 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Molecularly Imprinted Polymers for the Determination of Cancer Biomarkers
Autor: Pilvenyte, Greta ; Ratautaite, Vilma ; Boguzaite, Raimonda ; Ramanavicius, Arunas ; Viter, Roman ; Ramanavicius, Simonas
Assuntos: Antigens ; Biological markers ; Biomarkers ; Biomarkers, Tumor ; Biosensing Techniques ; Biosensors ; Blood ; Body fluids ; Breast cancer ; breast cancer biomarker ; Cancer ; conducting polymer (CP) ; Diagnosis ; disease biomarkers ; electrochemical sensor ; Electrodes ; ErbB-2 protein ; Growth factors ; Hepatocellular carcinoma ; Humans ; Imprinted polymers ; Liver cancer ; Low concentrations ; Molecular imprinting ; Molecular Imprinting - methods ; molecularly imprinted polymer (MIP) ; Molecularly Imprinted Polymers ; Nanomaterials ; Nanoparticles ; Neoplasms ; Neopterin ; Ovarian cancer ; Polymers ; Prostate cancer ; prostate cancer biomarker ; Proteins ; Review ; Sensors ; Systems analysis ; Urine
É parte de: International journal of molecular sciences, 2023-02, Vol.24 (4), p.4105
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Biomarkers can provide critical information about cancer and many other diseases; therefore, developing analytical systems for recognising biomarkers is an essential direction in bioanalytical chemistry. Recently molecularly imprinted polymers (MIPs) have been applied in analytical systems to determine biomarkers. This article aims to an overview of MIPs used for the detection of cancer biomarkers, namely: prostate cancer (PSA), breast cancer (CA15-3, HER-2), epithelial ovarian cancer (CA-125), hepatocellular carcinoma (AFP), and small molecule cancer biomarkers (5-HIAA and neopterin). These cancer biomarkers may be found in tumours, blood, urine, faeces, or other body fluids or tissues. The determination of low concentrations of biomarkers in these complex matrices is technically challenging. The overviewed studies used MIP-based biosensors to assess natural or artificial samples such as blood, serum, plasma, or urine. Molecular imprinting technology and MIP-based sensor creation principles are outlined. Analytical signal determination methods and the nature and chemical structure of the imprinted polymers are discussed. Based on the reviewed biosensors, the results are compared, and the most suitable materials for each biomarker are discussed.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Molecularly Imprinted Polymers for the Determination of Cancer Biomarkers

Pilvenyte, Greta ; Ratautaite, Vilma ; Boguzaite, Raimonda ; Ramanavicius, Arunas ; Viter, Roman ; Ramanavicius, Simonas

Switzerland: MDPI AG

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