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Surgical stress delays prostate involution in mice

Hassan, Sazzad ; Karpova, Yelena ; Flores, Anabel ; D'Agostino, Jr, Ralph ; Kulik, George Glinskii, Vladislav V.

PloS one, 2013-11, Vol.8 (11), p.e78175-e78175 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Surgical stress delays prostate involution in mice
Autor: Hassan, Sazzad ; Karpova, Yelena ; Flores, Anabel ; D'Agostino, Jr, Ralph ; Kulik, George
Glinskii, Vladislav V.
Assuntos: Ablation ; Adrenergic beta-Antagonists - pharmacology ; Adrenergic receptors ; Androgen Antagonists - pharmacology ; Androgens ; Androgens - metabolism ; Anesthesia ; Anilides - pharmacology ; Animals ; Antagonists ; Apoptosis ; Apoptosis - drug effects ; bcl-Associated Death Protein - genetics ; bcl-Associated Death Protein - metabolism ; Biology ; Cancer therapies ; Castration ; Deficient mutant ; Deprivation ; Drugs ; Epithelial cells ; Gene Expression Regulation ; Immunoglobulins ; Infrared imaging systems ; Insulin-like growth factors ; Isoflurane ; Kinases ; Male ; Medicine ; Metastasis ; Mice ; Mutation ; Nitriles - pharmacology ; Orchiectomy ; Ovarian cancer ; Phenylthiohydantoin - analogs & derivatives ; Phenylthiohydantoin - pharmacology ; Phosphorylation ; Propanolamines - pharmacology ; Prostate ; Prostate - drug effects ; Prostate - metabolism ; Prostate - surgery ; Prostate cancer ; Receptors, Adrenergic, beta-2 - metabolism ; Signal Transduction ; Signaling ; Standard deviation ; Stress ; Stress, Physiological ; Stresses ; Surgery ; Therapy ; Tosyl Compounds - pharmacology ; Urology
É parte de: PloS one, 2013-11, Vol.8 (11), p.e78175-e78175
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: SH GK. Performed the experiments: SH AF YK. Analyzed the data: SH GK RD. Contributed reagents/materials/analysis tools: SH. Wrote the paper: SH GK.
Descrição: Androgens control growth of prostate epithelial cells and androgen deprivation induces apoptosis, leading to prostate involution. We investigated the effects of surgical stress on prostate involution induced by androgen ablation and determined the underlying mechanisms. Androgen ablation in mice was induced by surgical castration and administration of the anti-androgenic drugs bicalutamide and MDV3100. Surgical stress was induced by sham castration under isoflurane anesthesia. Surgical stress delayed apoptosis and prostate involution induced by anti-androgenic drugs. These effects of stress were prevented by administering the selective beta2-adrenoreceptor antagonist ICI118,551 and were also blocked in BAD(3SA/WT) mice expressing phosphorylation-deficient mutant BAD3SA. These results indicate that apoptosis and prostate involution in response to androgen ablation therapy could be delayed by surgical stress via the beta2-adrenoreceptor/BAD signaling pathway. Thus, surgery could interfere with androgen ablation therapy, whereas administration of beta2-adrenoreceptor antagonists may enhance its efficacy.
Editor: United States: Public Library of Science
Idioma: Inglês

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Surgical stress delays prostate involution in mice

Hassan, Sazzad ; Karpova, Yelena ; Flores, Anabel ; D'Agostino, Jr, Ralph ; Kulik, George Glinskii, Vladislav V.

United States: Public Library of Science

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