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Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy

Ostuzzi, Giovanni ; Mazzi, Maria Angela ; Terlizzi, Samira ; Bertolini, Federico ; Aguglia, Andrea ; Bartoli, Francesco ; Bortolaso, Paola ; Callegari, Camilla ; Caroleo, Mariarita ; Carrà, Giuseppe ; Corbo, Mariangela ; D'Agostino, Armando ; Gastaldon, Chiara ; Lucii, Claudio ; Magliocco, Fabio ; Martinotti, Giovanni ; Nosé, Michela ; Ostinelli, Edoardo Giuseppe ; Papola, Davide ; Piccinelli, Marco Piero ; Piccoli, Alberto ; Purgato, Marianna ; Tabacchi, Tommaso ; Turrini, Giulia ; Ruggeri, Mirella ; Barbui, Corrado Mazza, Marianna

PloS one, 2018-08, Vol.13 (8), p.e0201371 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy
Autor: Ostuzzi, Giovanni ; Mazzi, Maria Angela ; Terlizzi, Samira ; Bertolini, Federico ; Aguglia, Andrea ; Bartoli, Francesco ; Bortolaso, Paola ; Callegari, Camilla ; Caroleo, Mariarita ; Carrà, Giuseppe ; Corbo, Mariangela ; D'Agostino, Armando ; Gastaldon, Chiara ; Lucii, Claudio ; Magliocco, Fabio ; Martinotti, Giovanni ; Nosé, Michela ; Ostinelli, Edoardo Giuseppe ; Papola, Davide ; Piccinelli, Marco Piero ; Piccoli, Alberto ; Purgato, Marianna ; Tabacchi, Tommaso ; Turrini, Giulia ; Ruggeri, Mirella ; Barbui, Corrado
Mazza, Marianna
Assuntos: Analysis ; Antipsychotic agents ; Antipsychotic drugs ; Antipsychotics ; Aripiprazole ; Bipolar disorder ; Comorbidity ; Complications and side effects ; Diagnosis ; Drug therapy ; Drug use ; Health aspects ; Health sciences ; Hospitals ; Males ; Maternal & child health ; Medicine and Health Sciences ; Mental disorders ; Mental health ; Metabolism ; Neurosciences ; Patient compliance ; Patients ; People and places ; Physical Sciences ; Prognosis ; Psychiatry ; Psychoses ; Psychotic disorders ; Psychotropic drugs ; Regression analysis ; Research and Analysis Methods ; Risk factors ; Risperidone ; Schizophrenia ; Social Sciences ; Statistical analysis ; Substance abuse treatment ; Suicide ; Surgery ; Systematic review
É parte de: PloS one, 2018-08, Vol.13 (8), p.e0201371
Notas: Competing Interests: The authors have declared that no competing interests exist.
Membership of the STAR Network is provided in the Acknowledgments.
Descrição: For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy. The STAR Network "Depot" Study is an observational, longitudinal, multicenter study involving 35 centers in Italy. In the cross-sectional phase, patients prescribed with LAIs were consecutively recruited and assessed over a period of 12 months. Descriptive statistics and multivariable logistic regression analyses were employed. Of the 451 recruited patients, 61% were males. The level of social and working functioning was heterogeneous, as was the severity of disease. Seventy-two per cent of the patients had a diagnosis of the schizophrenia spectrum. Seventy per cent were prescribed with second-generation antipsychotic (SGA) LAIs (mostly paliperidone, aripiprazole and risperidone). Compared to first-generation antipsychotic (FGA) LAIs, patients prescribed with SGA LAIs were more often younger; employed; with a diagnosis of the schizophrenia spectrum or bipolar disorder; with higher levels of affective symptoms; with fewer LAI prescriptions in the past. LAIs' prescribing practices appear to be more flexible as compared to the past, although this change is mostly restricted to SGA LAIs.
Editor: United States: Public Library of Science
Idioma: Inglês

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Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy

United States: Public Library of Science

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