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Exploring NAD^sup +^ metabolism in host-pathogen interactions

Mesquita, Inês ; Varela, Patrícia ; Belinha, Ana ; Gaifem, Joana ; Laforge, Mireille ; Vergnes, Baptiste ; Estaquier, Jérôme ; Silvestre, Ricardo

Cellular and Molecular Life Sciences, 2016, Vol.73 (6), p.1225 [Periódico revisado por pares]

Basel: Springer Nature B.V

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  • Título:
    Exploring NAD^sup +^ metabolism in host-pathogen interactions
  • Autor: Mesquita, Inês ; Varela, Patrícia ; Belinha, Ana ; Gaifem, Joana ; Laforge, Mireille ; Vergnes, Baptiste ; Estaquier, Jérôme ; Silvestre, Ricardo
  • Assuntos: Enzymes ; Infectious diseases ; Metabolism ; Molecular biology
  • É parte de: Cellular and Molecular Life Sciences, 2016, Vol.73 (6), p.1225
  • Descrição: Nicotinamide adenine dinucleotide (NAD^sup +^) is a vital molecule found in all living cells. NAD^sup +^ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate. The regulation of NAD^sup +^ metabolism has proven to be an adequate drug target for several diseases, including cancer, neurodegenerative or inflammatory diseases. Increasing interest has been given to NAD^sup +^ metabolism during innate and adaptive immune responses suggesting that its modulation could also be relevant during host-pathogen interactions. While the maintenance of NAD^sup +^ homeostatic levels assures an adequate environment for host cell survival and proliferation, fluctuations in NAD^sup +^ or biosynthetic precursors bioavailability have been described during host-pathogen interactions, which will interfere with pathogen persistence or clearance. Here, we review the double-edged sword of NAD^sup +^ metabolism during host-pathogen interactions emphasizing its potential for treatment of infectious diseases.
  • Editor: Basel: Springer Nature B.V
  • Idioma: Inglês
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