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Synergy of hypoxia relief and heat shock protein inhibition for phototherapy enhancement

Zhang, Gutian ; Cheng, Wenting ; Du, Lin ; Xu, Chuanjun ; Li, Jinlong

Journal of nanobiotechnology, 2021-01, Vol.19 (1), p.9-13, Article 9 [Periódico revisado por pares]

England: BioMed Central

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Título:
Synergy of hypoxia relief and heat shock protein inhibition for phototherapy enhancement
Autor: Zhang, Gutian ; Cheng, Wenting ; Du, Lin ; Xu, Chuanjun ; Li, Jinlong
Assuntos: Albumin ; Albumins ; Animals ; Anticancer properties ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - chemistry ; Antitumor activity ; Cancer ; Cancer therapies ; Cell Survival ; Cytotoxicity ; Efficiency ; Fever ; Heat ; Heat shock proteins ; Heat-Shock Proteins - drug effects ; HSP90 Heat-Shock Proteins - antagonists & inhibitors ; Hsp90 protein ; Hydrogen peroxide ; Hydrophobic and Hydrophilic Interactions ; Hydrophobicity ; Hyperthermia ; Hypoxia ; Hypoxia - drug therapy ; I.R. radiation ; Immunoglobulin M ; In vivo methods and tests ; Infrared Rays ; Irradiation ; Lasers ; Light therapy ; Male ; Manganese Compounds - chemistry ; Manganese dioxide ; Mice ; Mice, Inbred BALB C ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - therapeutic use ; Oxides - chemistry ; Photodynamic therapy ; Photosensitizing Agents - pharmacology ; Phototherapy ; Phototherapy - methods ; Proteins ; Reactive oxygen species ; Self-assembly ; Thermal resistance ; Tumor microenvironment ; Tumor Microenvironment - drug effects ; Xanthones - pharmacology
É parte de: Journal of nanobiotechnology, 2021-01, Vol.19 (1), p.9-13, Article 9
Descrição: Phototherapy is a promising strategy for cancer therapy by reactive oxygen species (ROS) of photodynamic therapy (PDT) and hyperthermia of photothermal therapy (PTT). However, the therapeutic efficacy was restricted by tumor hypoxia and thermal resistance of increased expression of heat shock protein (Hsp). In this study, we developed albumin nanoparticles to combine hypoxia relief and heat shock protein inhibition to overcome these limitations for phototherapy enhancement. Near-infrared photosensitizer (IR780) and gambogic acid (GA, Hsp90 inhibitor) were encapsulated into albumin nanoparticles via hydrophobic interaction, which was further deposited MnO on the surface to form IGM nanoparticles. Both in vitro and in vivo studies demonstrated that IGM could catalyze overexpress of hydrogen peroxide to relive hypoxic tumor microenvironment. With near infrared irradiation, the ROS generation was significantly increase for PDT enhancement. In addition, the release of GA was promoted by irradiation to bind with Hsp90, which could reduce cell tolerance to heat for PTT enhancement. As a result, IGM could achieve better antitumor efficacy with enhanced PDT and PTT. This study develops a facile approach to co-deliver IR780 and GA with self-assembled albumin nanoparticles, which could relive hypoxia and suppress Hsp for clinical application of cancer phototherapy.
Editor: England: BioMed Central
Idioma: Inglês

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Synergy of hypoxia relief and heat shock protein inhibition for phototherapy enhancement

Zhang, Gutian ; Cheng, Wenting ; Du, Lin ; Xu, Chuanjun ; Li, Jinlong

England: BioMed Central

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