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0072 The Effect Of Circadian Action Factor (caf) Of Artificial Light On The Level Of Melatonin And Subjective Alertness

Liu, Kai-Fa ; Chen, Tzung-Te ; Kao, Yu-Hsuan ; Huang, Ya-Chuan ; Yang, Chien-Ming

Sleep (New York, N.Y.), 2019-04, Vol.42 (Supplement_1), p.A30-A30 [Periódico revisado por pares]

Westchester: Oxford University Press

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  • Título:
    0072 The Effect Of Circadian Action Factor (caf) Of Artificial Light On The Level Of Melatonin And Subjective Alertness
  • Autor: Liu, Kai-Fa ; Chen, Tzung-Te ; Kao, Yu-Hsuan ; Huang, Ya-Chuan ; Yang, Chien-Ming
  • Assuntos: Light ; Melatonin ; Physiology ; Sleep
  • É parte de: Sleep (New York, N.Y.), 2019-04, Vol.42 (Supplement_1), p.A30-A30
  • Descrição: Introduction The invention of artificial light promoted the development of civilization, but it disrupts the normal regulation of human physiology and psychology, such as hormone synthesis, sleep-wake cycle, and the level of alertness. Previous researches found that high color temperature and Illuminance of light suppress pre-sleep melatonin secretion as well as reduce subjective alertness. Lately, a newly proposed formula, Equivalent Melaopic Lux (EML) = Circadian Action Factor (CAF) * Lux, suggests that CAF could be a better predictor for melatonin suppression effect. Hence, the present study examine this hypothesis by comparing the effects of lights with similar color temperature but difference CAF on melatonin suppression and subjective alertness. Methods 6 healthy students (19-20yo) without sleep or psychiatric disorder, participated in the study. They spent 5 nights in the sleep lab for the exposure to different lights: one dim-light night for baseline and four randomly assigned light conditions with different color temperature/CAF (A: 3419K/0.41; B:3453K/0.60; C: 5560K/0.65; D:5588K/0.91). They were exposed to the light condition starting at 1.5 hours before habitual bedtime to their habitual bedtime. Saliva samples were collected every 30 min from 3.5 hours before habituate bedtime to 30 min after assessing the level of melatonin. Results The melatonin level at habitual bedtime was analyzed. The melatonin level in condition A was higher than condition B and C. Pearson’s correlation showed significant positive correlation between melatonin level and subjective alertness in dim light condition (r= .30, p<.05). However, the correlation between melatonin and alertness became non-significant for all the four light conditions. Conclusion The preliminary results suggest that the higher CAF, the higher suppression of melatonin. Comparing to light temperature, CAF is a better index to predict the melatonin suppression effect of light. Moreover, the level of subjective alertness correlate positively with concentration of melatonin in the dim light. The correlation however is diminished with light exposure. This preliminary study suggest that CAF might be a better index to study the effects of light on human physiology. Support (If Any) ITRI
  • Editor: Westchester: Oxford University Press
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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