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Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material

Roosterman, Dirk ; Cottrell, Graeme Stuart

International journal of molecular sciences, 2021-01, Vol.22 (2), p.604 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material
Autor: Roosterman, Dirk ; Cottrell, Graeme Stuart
Assuntos: Acids ; Bacteria ; Biochemistry ; Biology ; Carbon dioxide ; Carboxylic acids ; Citric acid ; Citric Acid Cycle ; Dehydrogenases ; Energy ; Enzyme kinetics ; exercise ; Glucose ; Hydration ; Hypotheses ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; malic acid ; memory formation ; Metabolism ; Oxaloacetic acid ; Oxidation ; oxidative phosphorylation ; Pyruvate carboxylase ; Pyruvic acid ; Review ; succinic acid ; Tricarboxylic acid cycle
É parte de: International journal of molecular sciences, 2021-01, Vol.22 (2), p.604
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: In 1937, Sir H. A Krebs first published the Citric Acid Cycle, a unidirectional cycle with carboxylic acids. The original concept of the Citric Acid Cycle from Krebs' 1953 Nobel Prize lecture illustrates the unidirectional degradation of lactic acid to water, carbon dioxide and hydrogen. Here, we add the heart lactate dehydrogenase•proton-linked monocarboxylate transporter 1 complex, connecting the original Citric Acid Cycle to the flow of energy and material. The heart lactate dehydrogenase•proton-linked monocarboxylate transporter 1 complex catalyses the first reaction of the Citric Acid Cycle, the oxidation of lactate to pyruvate, and thus secures the provision of pyruvic acid. In addition, we modify Krebs' original concept by feeding the cycle with oxaloacetic acid. Our concept enables the integration of anabolic processes and allows adaption of the organism to recover ATP faster.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material

Roosterman, Dirk ; Cottrell, Graeme Stuart

Switzerland: MDPI AG

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