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Physical Properties and Antimicrobial Release Ability of Gentamicin-Loaded Apatite Cement/α-TCP Composites: An In Vitro Study

Sasaki, Kazuki ; Ninomiya, Yoshiaki ; Takechi, Masaaki ; Tsuru, Kanji ; Ishikawa, Kunio ; Shigeishi, Hideo ; Ohta, Kouji ; Aikawa, Tomonao

Materials, 2023-01, Vol.16 (3), p.995 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Physical Properties and Antimicrobial Release Ability of Gentamicin-Loaded Apatite Cement/α-TCP Composites: An In Vitro Study
Autor: Sasaki, Kazuki ; Ninomiya, Yoshiaki ; Takechi, Masaaki ; Tsuru, Kanji ; Ishikawa, Kunio ; Shigeishi, Hideo ; Ohta, Kouji ; Aikawa, Tomonao
Assuntos: alpha-tricalcium phosphate ; Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial agents ; Apatite ; apatite cement ; Biocompatibility ; Biomedical materials ; Calcium phosphate ; Calcium phosphates ; Cement paste ; Composite materials ; Composition ; Dental adhesives ; Dental glass ionomer cements ; Diffraction patterns ; Drug delivery systems ; Gentamicin ; Health aspects ; Humidity ; Hydroxyapatite ; Methods ; Mixing ratio ; Morphology ; Oral surgery ; Physical properties ; Properties ; Relative humidity ; Scanning electron microscopy ; Substitute bone ; Tensile strength ; X ray powder diffraction ; X-ray diffraction
É parte de: Materials, 2023-01, Vol.16 (3), p.995
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Apatite cement (AC), which has excellent osteoconductive ability, and alpha-tricalcium phosphate (α-TCP), which can be used for bone replacement, are useful bone substitute materials. The objective of this study was to clarify the physical properties and antimicrobial release ability of antibiotic-loaded AC/α-TCP composites in vitro. Gentamicin-loaded, rapid setting AC/α-TCP composites were prepared in 2 mixing ratios (10:3 and 10:6). The cement paste of AC/α-TCP composites was prepared in a plastic mold and dried in a thermostatic chamber at 37 °C and 100% relative humidity for 24 h. A diametral tensile strength test, powder X-ray diffraction analysis, and gentamicin release test were performed. The diametral tensile strengths of the AC/α-TCP composites were significantly less than that of AC alone. Powder X-ray diffraction patterns exhibited the characteristic peaks of hydroxyapatite in the AC/α-TCP composites and gentamicin-loaded AC/α-TCP composites. The concentration of the released gentamicin was maintained above the minimum inhibitory concentration of until Day 30 in both the gentamicin-loaded AC/α-TCP composites (10:3 and 10:6). Our results suggest that a gentamicin-loaded AC/α-TCP composite has potential as a drug delivery system. Further study is essential to investigate the antimicrobial activity and safety of the gentamicin-loaded AC/α-TCP composites in animal models.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Physical Properties and Antimicrobial Release Ability of Gentamicin-Loaded Apatite Cement/α-TCP Composites: An In Vitro Study

Sasaki, Kazuki ; Ninomiya, Yoshiaki ; Takechi, Masaaki ; Tsuru, Kanji ; Ishikawa, Kunio ; Shigeishi, Hideo ; Ohta, Kouji ; Aikawa, Tomonao

Switzerland: MDPI AG

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