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Ruthenium(II) carbonyl complexes containing S-methylisothiosemicarbazone based tetradentate ligand: synthesis, characterization and biological applications

Selvamurugan, Sellappan ; Ramachandran, Rangasamy ; Viswanathamurthi, Periasamy

Biometals, 2013-10, Vol.26 (5), p.741-753 [Periódico revisado por pares]

Dordrecht: Springer Netherlands

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Título:
Ruthenium(II) carbonyl complexes containing S-methylisothiosemicarbazone based tetradentate ligand: synthesis, characterization and biological applications
Autor: Selvamurugan, Sellappan ; Ramachandran, Rangasamy ; Viswanathamurthi, Periasamy
Assuntos: Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Antioxidants ; Biochemistry ; Biomedical and Life Sciences ; Biomedical research ; Biosynthesis ; Biotechnology ; Cancer ; Carbon Monoxide - chemistry ; Cell Biology ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Cleavage ; Deoxyribonucleic acid ; DNA Cleavage - drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Electrophoresis, Agar Gel ; Free radicals ; Human ; Humans ; Life Sciences ; Ligands ; MCF-7 Cells ; Medicine/Public Health ; Microbiology ; Molecular Structure ; Organometallic Compounds - chemical synthesis ; Organometallic Compounds - chemistry ; Organometallic Compounds - pharmacology ; Pharmacology/Toxicology ; Plant Physiology ; Ruthenium - chemistry ; Schiff bases ; Schiff Bases - chemistry ; Spectra ; Structure-Activity Relationship ; Thiosemicarbazones - chemistry
É parte de: Biometals, 2013-10, Vol.26 (5), p.741-753
Notas: ObjectType-Article-1
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Descrição: A series of hexa-coordinated ruthenium(II) complexes of the type [Ru(CO)(B)L n ] ( n = 1–4; B = PPh 3 , AsPh 3 or Py) have been synthesized by reacting dibasic quadridentate Schiff base ligands H 2 L n ( n = 1–4) with starting complexes [RuHCl(CO)(EPh 3 ) 2 (B)] (E = P or As; B = PPh 3 , AsPh 3 or Py). The synthesized complexes were characterized using elemental and various spectral studies including UV–Vis, FT-IR, NMR ( 1 H, 13 C and 31 P) and mass spectroscopy. An octahedral geometry was tentatively proposed for all the complexes based on the spectral data obtained. The experiments on antioxidant activity showed that the ruthenium(II) S -methylisothiosemicarbazone Schiff base complexes exhibited good scavenging activity against various free radicals (DPPH, OH and NO). The in vitro cytotoxicity of these complexes has been evaluated by MTT assay. The results demonstrate that the complexes have good anticancer activities against selected cancer cell line, human breast cancer cell line (MCF-7) and human skin carcinoma cell line (A431). The DNA cleavage studies showed that the complexes have better cleavage of pBR 322 DNA.
Editor: Dordrecht: Springer Netherlands
Idioma: Inglês;Holandês

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Ruthenium(II) carbonyl complexes containing S-methylisothiosemicarbazone based tetradentate ligand: synthesis, characterization and biological applications

Selvamurugan, Sellappan ; Ramachandran, Rangasamy ; Viswanathamurthi, Periasamy

Dordrecht: Springer Netherlands

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