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SUDOSCAN: A Simple, Rapid, and Objective Method with Potential for Screening for Diabetic Peripheral Neuropathy

Selvarajah, Dinesh ; Cash, Tom ; Davies, Jennifer ; Sankar, Adithya ; Rao, Ganesh ; Grieg, Marni ; Pallai, Shillo ; Gandhi, Rajiv ; Wilkinson, Iain D ; Tesfaye, Solomon Santanelli, di Pompeo d’Illasi, Fabio

PloS one, 2015-10, Vol.10 (10), p.e0138224-e0138224 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
SUDOSCAN: A Simple, Rapid, and Objective Method with Potential for Screening for Diabetic Peripheral Neuropathy
Autor: Selvarajah, Dinesh ; Cash, Tom ; Davies, Jennifer ; Sankar, Adithya ; Rao, Ganesh ; Grieg, Marni ; Pallai, Shillo ; Gandhi, Rajiv ; Wilkinson, Iain D ; Tesfaye, Solomon
Santanelli, di Pompeo d’Illasi, Fabio
Assuntos: Adult ; Analysis ; Carts ; Case-Control Studies ; Classification ; Conductance ; Conduction ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes Mellitus, Type 1 - complications ; Diabetic neuropathies ; Diabetic Neuropathies - complications ; Diabetic Neuropathies - diagnosis ; Diabetic Neuropathies - physiopathology ; Diabetic neuropathy ; Diagnosis ; Electrochemistry ; Feet ; Female ; Galvanic Skin Response ; Humans ; Life assessment ; Male ; Medical screening ; Methods ; Middle Aged ; Nerve conduction ; Neural Conduction ; Neurology ; Neurophysiology ; Peripheral neuropathy ; Questionnaires ; Resistance ; Risk analysis ; ROC Curve ; Screening ; Sensitivity ; Skin ; Studies ; Teaching hospitals ; Time Factors
É parte de: PloS one, 2015-10, Vol.10 (10), p.e0138224-e0138224
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: ST and DS are members of the scientific advisory board for Impeto Medical. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Conceived and designed the experiments: DS GR RG IDW ST. Performed the experiments: DS TC JD AS MG SP. Analyzed the data: DS TC RG IDW ST. Wrote the paper: DS TC JD AS GR MG SP RG IDW ST.
Descrição: Clinical methods of detecting diabetic peripheral neuropathy (DPN) are not objective and reproducible. We therefore evaluated if SUDOSCAN, a new method developed to provide a quick, non-invasive and quantitative assessment of sudomotor function can reliably screen for DPN. 70 subjects (45 with type 1 diabetes and 25 healthy volunteers [HV]) underwent detailed assessments including clinical, neurophysiological and 5 standard cardiovascular reflex tests (CARTs). Using the American Academy of Neurology criteria subjects were classified into DPN and No-DPN groups. Based on CARTs subjects were also divided into CAN, subclinical-CAN and no-CAN. Sudomotor function was assessed with measurement of hand and foot Electrochemical Skin Conductance (ESC) and calculation of the CAN risk score. Foot ESC (μS) was significantly lower in subjects with DPN [n = 24; 53.5(25.1)] compared to the No-DPN [77.0(7.9)] and HV [77.1(14.3)] groups (ANCOVA p<0.001). Sensitivity and specificity of foot ESC for classifying DPN were 87.5% and 76.2%, respectively. The area under the ROC curve (AUC) was 0.85. Subjects with CAN had significantly lower foot [55.0(28.2)] and hand [53.5(19.6)] ESC compared to No-CAN [foot ESC, 72.1(12.2); hand ESC 64.9(14.4)] and HV groups (ANCOVA p<0.001 and 0.001, respectively). ROC analysis of CAN risk score to correctly classify CAN revealed a sensitivity of 65.0% and specificity of 80.0%. AUC was 0.75. Both foot and hand ESC demonstrated strong correlation with individual parameters and composite scores of nerve conduction and CAN. SUDOSCAN, a non-invasive and quick test, could be used as an objective screening test for DPN in busy diabetic clinics, insuring adherence to current recommendation of annual assessments for all diabetic patients that remains unfulfilled.
Editor: United States: Public Library of Science
Idioma: Inglês

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SUDOSCAN: A Simple, Rapid, and Objective Method with Potential for Screening for Diabetic Peripheral Neuropathy

Selvarajah, Dinesh ; Cash, Tom ; Davies, Jennifer ; Sankar, Adithya ; Rao, Ganesh ; Grieg, Marni ; Pallai, Shillo ; Gandhi, Rajiv ; Wilkinson, Iain D ; Tesfaye, Solomon Santanelli, di Pompeo d’Illasi, Fabio

United States: Public Library of Science

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