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Titania Coated Upconversion Nanoparticles for Near-Infrared Light Triggered Photodynamic Therapy

Lucky, Sasidharan Swarnalatha ; Muhammad Idris, Niagara ; Li, Zhengquan ; Huang, Kai ; Soo, Khee Chee ; Zhang, Yong

ACS nano, 2015-01, Vol.9 (1), p.191-205 [Periódico revisado por pares]

United States: American Chemical Society

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Titania Coated Upconversion Nanoparticles for Near-Infrared Light Triggered Photodynamic Therapy
Autor: Lucky, Sasidharan Swarnalatha ; Muhammad Idris, Niagara ; Li, Zhengquan ; Huang, Kai ; Soo, Khee Chee ; Zhang, Yong
Assuntos: Animals ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - pathology ; Cell Death - drug effects ; Cell Death - radiation effects ; Cell Line, Tumor ; Darkness ; Effectiveness ; Excitation ; Female ; Hemolysis - drug effects ; Humans ; Infrared Rays ; Macrophages - metabolism ; Mice ; Mouth Neoplasms - diagnosis ; Mouth Neoplasms - drug therapy ; Mouth Neoplasms - pathology ; Nanomedicine - methods ; Nanoparticles ; Nanostructure ; Photochemotherapy - methods ; Photodynamic therapy ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - metabolism ; Photosensitizing Agents - pharmacology ; Photosensitizing Agents - toxicity ; Polyethylene glycol ; Polyethylene Glycols - chemistry ; Reactive Oxygen Species - metabolism ; Titanium - chemistry ; Titanium - metabolism ; Titanium - pharmacology ; Titanium - toxicity ; Titanium dioxide ; Upconversion
É parte de: ACS nano, 2015-01, Vol.9 (1), p.191-205
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SourceType-Scholarly Journals-1
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Descrição: Because of the limited penetration depth of visible light that generally excites most of the available photosensitizers (PSs), conventional photodynamic therapy (PDT) is limited to the treatment of superficial and flat lesions. Recently, the application of deep penetrating near-infrared (NIR) light excitable upconversion nanoparticles (UCNs) in conjunction with PDT has shown to have clear potential in the treatment of solid tumors due to its ability to penetrate thick tissue. However, various constructs developed so far have certain limitations such as poor or unstable PS loading, reducing their therapeutic efficacy and limiting their application to solution or cell-based studies. In this work, we present a method to fabricate uniform core–shell structured nanoconstruct with a thin layer of photocatalyst or PS–titanium dioxide (TiO2) stably coated on individual UCN core. Our design allows controllable and highly reproducible PS loading, preventing any leakage of PS compared to previously developed nanoconstructs, thus ensuring repeatable PDT results. Further surface modification of the developed nanoconstructs with polyethylene glycol (PEG) rendered them biocompatible, demonstrating good therapeutic efficacy both in vitro and in vivo.
Editor: United States: American Chemical Society
Idioma: Inglês

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Titania Coated Upconversion Nanoparticles for Near-Infrared Light Triggered Photodynamic Therapy

Lucky, Sasidharan Swarnalatha ; Muhammad Idris, Niagara ; Li, Zhengquan ; Huang, Kai ; Soo, Khee Chee ; Zhang, Yong

United States: American Chemical Society

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