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Curcumin supplementation improves oxidative stress and inflammation biomarkers in patients undergoing hemodialysis: a secondary analysis of a randomized controlled trial

Alvarenga, Livia ; Cardozo, Ludmila F. M. F. ; Da Cruz, Beatriz O. ; Paiva, Bruna R. ; Fouque, Denis ; Mafra, Denise

International urology and nephrology, 2022-10, Vol.54 (10), p.2645-2652 [Periódico revisado por pares]

Dordrecht: Springer Netherlands

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Título:
Curcumin supplementation improves oxidative stress and inflammation biomarkers in patients undergoing hemodialysis: a secondary analysis of a randomized controlled trial
Autor: Alvarenga, Livia ; Cardozo, Ludmila F. M. F. ; Da Cruz, Beatriz O. ; Paiva, Bruna R. ; Fouque, Denis ; Mafra, Denise
Assuntos: Biomarkers ; Curcumin ; Enzyme-linked immunosorbent assay ; Hemodialysis ; Inflammation ; Interleukin 6 ; Kidney diseases ; Life Sciences ; Lipid peroxidation ; Low density lipoprotein ; Medicine ; Medicine & Public Health ; Nephrology ; Nephrology - Original Paper ; Oxidative stress ; Patients ; Plasma levels ; Supplements ; Thiobarbituric acid ; Tumor necrosis factor-α ; Urology
É parte de: International urology and nephrology, 2022-10, Vol.54 (10), p.2645-2652
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-News-3
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Descrição: Background and objectives Recent studies have shed light on the potential role of curcumin in mitigating inflammation in patients with chronic kidney disease (CKD). This study aimed to evaluate the effects of curcumin supplementation on plasma levels of markers of inflammation and oxidative stress in patients with CKD undergoing hemodialysis (HD). Methods These are secondary exploratory analyses from a previous double-blind, randomized controlled pilot study registered under ClinicalTrials.gov Identifier no. NCT00123456. It included 28 hemodialysis patients from a previous study divided into two groups: curcumin group (receiving juice with 2.5 g of turmeric 3×/week for 12 weeks) and a control group. The TNF-α, IL-6 and Ox-LDL plasma levels were measured by sandwich enzyme immunoassays ELISA; lipid peroxidation was measured by the reaction between malondialdehyde (MDA) and thiobarbituric acid. Results After 12 weeks of supplementation with curcumin, the TNF-α plasma levels were significantly reduced [from 15.0 (8.23–73.3) to 6.17 (1.11–55.0) pg/mL, p = 0.01]. Conclusion 12 weeks of treatment with curcumin in HD patients resulted in a reduction in the biomarker of inflammation (TNF-α), confirming our previous hypothesis that curcumin has an anti-inflammatory effect.
Editor: Dordrecht: Springer Netherlands
Idioma: Inglês

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Curcumin supplementation improves oxidative stress and inflammation biomarkers in patients undergoing hemodialysis: a secondary analysis of a randomized controlled trial

Alvarenga, Livia ; Cardozo, Ludmila F. M. F. ; Da Cruz, Beatriz O. ; Paiva, Bruna R. ; Fouque, Denis ; Mafra, Denise

Dordrecht: Springer Netherlands

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