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Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation

Kacem, Houda ; Almeida, Aymeric ; Cherbuin, Nicolas ; Vozenin, Marie-Catherine

International journal of radiation biology, 2022-03, Vol.98 (3), p.506-516 [Periódico revisado por pares]

England: Taylor & Francis

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  • Título:
    Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation
  • Autor: Kacem, Houda ; Almeida, Aymeric ; Cherbuin, Nicolas ; Vozenin, Marie-Catherine
  • Assuntos: Clinical Protocols ; FLASH-RT ; Humans ; Neoplasms - radiotherapy ; Photons ; plasmid ; pre-clinical models ; Radiation Oncology ; Radiobiology ; Radiotherapy Dosage ; ROS ; Ultra-high dose rate
  • É parte de: International journal of radiation biology, 2022-03, Vol.98 (3), p.506-516
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-2
  • Descrição: A reemergence of research implementing radiation delivery at ultra-high dose rates (UHDRs) has triggered intense interest in the radiation sciences and has opened a new field of investigation in radiobiology. Much of the promise of UHDR irradiation involves the FLASH effect, an in vivo biological response observed to maintain anti-tumor efficacy without the normal tissue complications associated with standard dose rates. The FLASH effect has been validated primarily, using intermediate energy electron beams able to deliver high doses (>7 Gy) in a very short period of time (<200 ms), but has also been found with photon and proton beams. The clinical implications of this new area of research are highly significant, as FLASH radiotherapy (FLASH-RT) has the potential to enhance the therapeutic index, opening new possibilities for eradicating radio-resistant tumors without toxicity. As pioneers in this field, our group has developed a multidisciplinary research team focused on investigating the mechanisms and clinical translation of the FLASH effect. Here, we review the field of UHDR, from the physico-chemical to the biological mechanisms.
  • Editor: England: Taylor & Francis
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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