Idioma:

The utility of urinary biomarker panel in predicting renal pathology and treatment response in Chinese lupus nephritis patients

Liu, Li ; Wang, Ran ; Ding, Huihua ; Tian, Lei ; Gao, Ting ; Bao, Chunde Kuwana, Masataka

PloS one, 2020-10, Vol.15 (10), p.e0240942-e0240942 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
The utility of urinary biomarker panel in predicting renal pathology and treatment response in Chinese lupus nephritis patients
Autor: Liu, Li ; Wang, Ran ; Ding, Huihua ; Tian, Lei ; Gao, Ting ; Bao, Chunde
Kuwana, Masataka
Assuntos: Adult ; Age ; Autoimmune diseases ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomarkers - urine ; Biopsy ; Calbindin ; Care and treatment ; Cell adhesion & migration ; China ; Correlation ; Correlation analysis ; Creatinine ; Cystatin ; Cystatin C ; Data collection ; Diagnosis ; Emergency medical care ; Female ; Gene Expression Regulation ; Humans ; Induction therapy ; Interleukin 18 ; Kidney - pathology ; Kidney diseases ; Kidney function tests ; Kidneys ; Lupus ; Lupus nephritis ; Lupus Nephritis - diagnosis ; Lupus Nephritis - drug therapy ; Lupus Nephritis - pathology ; Lupus Nephritis - urine ; Male ; Medical treatment ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Monocyte chemoattractant protein 1 ; Nephritis ; Neutrophils ; Normal distribution ; Pathology ; Prognosis ; Proteins ; Proteomics ; Proteomics - methods ; Retrospective Studies ; Rheumatology ; Severity of Illness Index ; Software ; Systemic lupus erythematosus ; Urine ; Variance analysis ; Vascular cell adhesion molecule 1 ; Young Adult
É parte de: PloS one, 2020-10, Vol.15 (10), p.e0240942-e0240942
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Given the urgent need for non-invasive biomarkers of LN, we aim to identify novel urinary biomarkers that facilitate diagnosis, assessment of disease activity and prediction of treatment response in a retrospective SLE cohort. A total of 154 SLE patients and 55 healthy controls were enrolled, among whom 73 were active LN patients. We measured renal activity by renal SLEDAI. The treatment response of the active LN patients who finished 6-month induction therapy was assessed based on the American College of Rheumatology response criteria. The expression levels of 10 urinary biomarkers (UBMs): β2-MG, calbindin D, cystatin C, IL-18, KIM-1, MCP-1, nephrin, NGAL, VCAM-1, and VDBP were tested using Luminex high-throughput proteomics technology. All but urinary nephrin levels were significantly increased in active LN compared to healthy controls. uCystatinC, uMCP-1, uKIM-1 levels were significantly higher in active LN group compared to inactive LN group. Correlation analysis revealed positive correlation between uCystatinC, uKIM-1, uMCP-1, uNGAL, uVDBP and RSLEDAI score. In renal pathology, uCystatinC, uKIM-1, uVCAM-1, and uVDBP positively correlated with activity index (AI) while uVCAM-1 positively correlated with chronicity index (CI). Moreover, the combination of uVCAM-1, uCystatinC, uKIM-1 discriminated proliferative LN from membranous LN with an AUC of 0.80 (95%CI: 0.69-0.90). Most importantly, baseline uNGAL demonstrated good prediction ability to discriminate responders from non-responders in active LN patients after 6-month induction therapy. Using a multiplex bead technique, we have identified the combination of uVCAM-1, uCystatinC, uKIM-1 as a biomarker panel to reflect renal pathology and NGAL as a promising urinary biomarker to both reflect disease activity and predict treatment response.
Editor: United States: Public Library of Science
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 17 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

The utility of urinary biomarker panel in predicting renal pathology and treatment response in Chinese lupus nephritis patients

Liu, Li ; Wang, Ran ; Ding, Huihua ; Tian, Lei ; Gao, Ting ; Bao, Chunde Kuwana, Masataka

United States: Public Library of Science

Buscando em bases de dados remotas. Favor aguardar.