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Effects of hypernatraemia in the central nervous system and its therapy in rats and rabbits

Ayus, J C ; Armstrong, D L ; Arieff, A I

The Journal of physiology, 1996-04, Vol.492 (Pt 1), p.243-255 [Periódico revisado por pares]

England: The Physiological Society

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Título:
Effects of hypernatraemia in the central nervous system and its therapy in rats and rabbits
Autor: Ayus, J C ; Armstrong, D L ; Arieff, A I
Assuntos: Amino Acids - metabolism ; Animals ; Body Fluid Compartments - drug effects ; Brain - pathology ; Brain Chemistry - drug effects ; Brain Edema - etiology ; Brain Edema - pathology ; Carbon Dioxide - metabolism ; Female ; Hydrogen-Ion Concentration - drug effects ; Hypernatremia - metabolism ; Hypernatremia - pathology ; Hypernatremia - therapy ; Male ; Osmolar Concentration ; Oxygen - metabolism ; Potassium - metabolism ; Rabbits ; Rats ; Rats, Sprague-Dawley ; Sodium - metabolism ; Sodium Chloride - therapeutic use ; Water - metabolism
É parte de: The Journal of physiology, 1996-04, Vol.492 (Pt 1), p.243-255
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: 1. We studied the effects of acute (1 or 4 h) and chronic (1 week) hypernatraemia (plasma [Na+], 170-190 mM) on brain histology, and brain water and solute contents in rats and rabbits. 2. In rabbits with acute hypernatraemia, there was significant loss of intracellular brain water, with increases in brain [Na+ + K+], amino acid concentration, and undetermined solute (idiogenic osmole). After 1 week of recovery, brain intracellular water content had returned to normal. 3. In hypernatraemic rats there was myelinolysis of brain white matter, with karyorrhexis and necrosis of neurons. 4. Hypernatraemic rabbits were treated with 77 mM NaCl (i.v.) to normalize plasma [Na+] over 4-24 h intervals. Therapy of either acute or chronic hypernatraemia resulted in significant brain oedema because brain osmolality failed to decrease at the same rate as plasma osmolality. 5. It is concluded that: (a) untreated hypernatraemia results in brain lesions demonstrating myelinolysis and cellular necrosis; (b) normalization of hypernatraemia over 4-24 h results in cerebral oedema, due primarily to failure of brain amino acids and idiogenic osmoles to dissipate as plasma [Na+] is decreased to normal.
Editor: England: The Physiological Society
Idioma: Inglês

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Effects of hypernatraemia in the central nervous system and its therapy in rats and rabbits

Ayus, J C ; Armstrong, D L ; Arieff, A I

England: The Physiological Society

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