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Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology

Kierans, S. J. ; Taylor, C. T.

The Journal of physiology, 2021-01, Vol.599 (1), p.23-37 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

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  • Título:
    Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology
  • Autor: Kierans, S. J. ; Taylor, C. T.
  • Assuntos: Angiogenesis ; Bioenergetics ; Cell Hypoxia ; Electron transport ; Endothelial Cells ; Energy Metabolism ; Glycolysis ; HIF ; Homeostasis ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit ; Metabolism ; Mitochondria ; Physiology ; Transcription ; Tumors
  • É parte de: The Journal of physiology, 2021-01, Vol.599 (1), p.23-37
  • Notas: This is an Editor's Choice article from the 1 January 2021 issue.
    Edited by: Ian Forsythe & Paul Greenhaff
    ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP levels. This hypoxia‐induced reprogramming of metabolism is key to satisfying cellular energetic requirements during acute hypoxic stress. At a transcriptional level, this metabolic switch can be regulated by several pathways including the hypoxia inducible factor‐1α (HIF‐1α) which induces an increased expression of glycolytic enzymes. While this increase in glycolytic flux is beneficial for maintaining bioenergetic homeostasis during hypoxia, the pathways mediating this increase can also be exploited by cancer cells to promote tumour survival and growth, an area which has been extensively studied. It has recently become appreciated that increased glycolytic metabolism in hypoxia may also have profound effects on cellular physiology in hypoxic immune and endothelial cells. Therefore, understanding the mechanisms central to mediating this reprogramming are of importance from both physiological and pathophysiological standpoints. In this review, we highlight the role of HIF‐1α in the regulation of hypoxic glycolysis and its implications for physiological processes such as angiogenesis and immune cell effector function. figure legend Schematic outlining the functional physiological consequences of enhanced glycolytic metabolism in endothelial cells and immune cells.
  • Editor: England: Wiley Subscription Services, Inc
  • Idioma: Inglês
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