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Serum prokineticin-2 in prepubertal and adult Klinefelter individuals

Fiore, Marco ; Tarani, Luigi ; Radicioni, Antonio ; Spaziani, Matteo ; Ferraguti, Giampiero ; Putotto, Carolina ; Gabanella, Francesca ; Maftei, Daniela ; Lattanzi, Roberta ; Minni, Antonio ; Greco, Antonio ; Tarani, Francesca ; Petrella, Carla

Canadian journal of physiology and pharmacology, 2022-02, Vol.100 (2), p.151-157 [Peer Reviewed Journal]

1840 Woodward Drive, Suite 1, Ottawa, ON K2C 0P7: Canadian Science Publishing

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Title:
Serum prokineticin-2 in prepubertal and adult Klinefelter individuals
Author: Fiore, Marco ; Tarani, Luigi ; Radicioni, Antonio ; Spaziani, Matteo ; Ferraguti, Giampiero ; Putotto, Carolina ; Gabanella, Francesca ; Maftei, Daniela ; Lattanzi, Roberta ; Minni, Antonio ; Greco, Antonio ; Tarani, Francesca ; Petrella, Carla
Subjects: Adolescent ; Adult ; adultes ; adults ; Biomarkers - blood ; Causes of ; Chemokines ; Child ; Complications and side effects ; Development and progression ; Gastrointestinal Hormones - blood ; Health aspects ; Humans ; Infertility ; Infertility, Male ; Infertility, Male - diagnosis ; Infertility, Male - etiology ; infertilité ; Karyotype ; Karyotypes ; Klinefelter syndrome ; Klinefelter Syndrome - blood ; Klinefelter Syndrome - complications ; Klinefelter's syndrome ; Life cycle, Human ; Male ; Measurement ; Middle Aged ; Neuropeptides - blood ; Peptides ; Physiological aspects ; prepubertal ; procinéticine 2 ; prokineticin-2 ; prépuberté ; Serum levels ; Sexual Maturation ; Spermatogenesis ; syndrome de Klinefelter ; Testosterone ; Testosterone - deficiency ; Young Adult
Is Part Of: Canadian journal of physiology and pharmacology, 2022-02, Vol.100 (2), p.151-157
Notes: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: The prokineticin-2 (PROK2) is a small peptide belonging to the prokineticin family. In humans and rodents this chemokine is primarily involved in the control of central and peripheral reproductive processes. Klinefelter’s syndrome (KS) is the first cause of male genetic infertility, due to an extra X chromosome, which may occur with a classical karyotype (47, XXY) or mosaic forms (46, XY/47, XXY). In affected subjects, pubertal maturation usually begins at an adequate chronological age, but when development is almost complete, they display a primary gonadal failure, with early spermatogenesis damage, and later onset of testosterone insufficiency. Thus, the main aim of the present study was to investigate the serum levels of PROK2 in prepubertal and adult KS patients, comparing them with healthy subjects. We showed for the first time the presence of PROK2 in the children serum but with significant changes in KS individuals. Indeed, compared with healthy subjects characterized by PROK2 serum elevation during the growth, KS individuals showed constant serum levels during the sexual maturation phase (higher during the prepubertal phase but lower during the adult age). In conclusion, these data indicate that in KS individuals PROK2 may be considered a biomarker for investigating the SK infertility process.
Publisher: 1840 Woodward Drive, Suite 1, Ottawa, ON K2C 0P7: Canadian Science Publishing
Language: English

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Serum prokineticin-2 in prepubertal and adult Klinefelter individuals

Fiore, Marco ; Tarani, Luigi ; Radicioni, Antonio ; Spaziani, Matteo ; Ferraguti, Giampiero ; Putotto, Carolina ; Gabanella, Francesca ; Maftei, Daniela ; Lattanzi, Roberta ; Minni, Antonio ; Greco, Antonio ; Tarani, Francesca ; Petrella, Carla

1840 Woodward Drive, Suite 1, Ottawa, ON K2C 0P7: Canadian Science Publishing

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