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Natural disease history of the D2‐mdx mouse model for Duchenne muscular dystrophy

Putten, Maaike ; Putker, Kayleigh ; Overzier, Maurice ; Adamzek, W. A. ; Pasteuning-Vuhman, Svetlana ; Plomp, Jaap J. ; Aartsma-Rus, Annemieke

The FASEB journal, 2019-07, Vol.33 (7), p.8110-8124 [Periódico revisado por pares]

United States: Federation of American Societies for Experimental Biology

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Título:
Natural disease history of the D2‐mdx mouse model for Duchenne muscular dystrophy
Autor: Putten, Maaike ; Putker, Kayleigh ; Overzier, Maurice ; Adamzek, W. A. ; Pasteuning-Vuhman, Svetlana ; Plomp, Jaap J. ; Aartsma-Rus, Annemieke
Assuntos: Animals ; calcification ; Disease Models, Animal ; Female ; fibrosis ; Male ; Mice ; Mice, Inbred mdx ; muscle function ; Muscular Dystrophy, Animal - genetics ; Muscular Dystrophy, Animal - metabolism ; Muscular Dystrophy, Animal - pathology ; Muscular Dystrophy, Animal - physiopathology ; Muscular Dystrophy, Duchenne - genetics ; Muscular Dystrophy, Duchenne - metabolism ; Muscular Dystrophy, Duchenne - pathology ; Muscular Dystrophy, Duchenne - physiopathology ; pathology ; regeneration
É parte de: The FASEB journal, 2019-07, Vol.33 (7), p.8110-8124
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: ABSTRACT The C57BL/10ScSn‐Dmdmdx/J (BL10‐mdx) mouse has been the most commonly used model for Duchenne muscular dystrophy (DMD) for decades. Their muscle dysfunction and pathology is, however, less severe than in patients with DMD, which complicates preclinical studies. Recent discoveries indicate that disease severity is exacerbated when muscular dystrophy mouse models are generated on a DBA2/J genetic background. Knowledge on the natural history of animal models is pivotal for high‐quality preclinical testing. However, for BL10‐mdx mice on a DBA2/J background (D2‐mdx), limited data are available. We addressed this gap in the natural history knowledge. First, we compared histopathological aspects in skeletal muscles of young D2‐mdx, BL10‐mdx, and wild‐type mice. Pathology was more pronounced in D2‐mdx mice and differed in severity between muscles within individuals. Secondly, we subjected D2‐mdx mice to a functional test regime for 34 weeks and identified that female D2‐mdx mice outperform severely impaired males, making females less useful for functional preclinical studies. Direct comparisons between 10‐ and 34‐wk‐old D2‐mdx mice revealed that disease pathology ameliorates with age. Heart pathology was progressive, with some features already evident at a young age. This natural history study of the D2‐mdx mouse will be instrumental for experimental design of future preclinical studies.—Van Putten, M., Putker, K., Overzier, M., Adamzek, W. A., Pasteuning‐Vuhman, S., Plomp, J. J., Aartsma‐Rus, A. Natural disease history of the D2‐mdx mouse model for Duchenne muscular dystrophy. FASEB J. 33, 8110–8124 (2019). www.fasebj.org
Editor: United States: Federation of American Societies for Experimental Biology
Idioma: Inglês

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Natural disease history of the D2‐mdx mouse model for Duchenne muscular dystrophy

Putten, Maaike ; Putker, Kayleigh ; Overzier, Maurice ; Adamzek, W. A. ; Pasteuning-Vuhman, Svetlana ; Plomp, Jaap J. ; Aartsma-Rus, Annemieke

United States: Federation of American Societies for Experimental Biology

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