Discovery of a Potent and Selective PI3Kδ Inhibitor ( S )-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4 H -quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models

Shukla, Manojkumar R ; Patra, Sukanya ; Verma, Mahip ; Sadasivam, Gayathri ; Jana, Nirmal ; Mahangare, Sachin J ; Vidhate, Prashant ; Lagad, Dipak ; Tarage, Anand ; Cheemala, Murthy ; Kulkarni, Chaitanya ; Bhagwat, Shankar ; Chaudhari, Vinod D ; Sayyed, Majid ; Pachpute, Vipul ; Phadtare, Ramesh ; Gole, Gopal ; Phukan, Samiron ; Sunkara, Brahmam ; Samant, Charudatt ; Shingare, Manisha ; Naik, Aditya ; Trivedi, Sneha ; Marisetti, Ajit Kumar ; Reddy, Madhusudhan ; Gholve, Milind ; Mahajan, Nilesh ; Sabde, Sudeep ; Patil, Vinod ; Modi, Dipak ; Mehta, Maneesh ; Nigade, Prashant ; Tamane, Kaustubh ; Tota, Swati ; Goyal, Hemant ; Volam, Harish ; Pawar, Shashikant ; Ahirrao, Prajakta ; Dinchhana, Lal ; Mallurwar, Sadanand ; Akarte, Atul ; Bokare, Anand ; Kanhere, Rupesh ; Reddy, Neetinkumar ; Koul, Sarita ; Dandekar, Manoj ; Singh, Minakshi ; Bernstein, Peter R ; Narasimham, Lakshmi ; Bhonde, Mandar ; Gundu, Jayasagar ; Goel, Rajan ; Kulkarni, Sanjeev ; Sharma, Sharad ; Kamboj, Rajender Kumar ; Palle, Venkata P

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14700-14723 [Periódico revisado por pares]

United States

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