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HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs

Cohen, T.J., Duke University, Durham, USA ; Choi, M.C., Duke University, Durham, USA ; Kapur, M., Duke University, Durham, USA ; Lira, V.A., University of Virginia, Charlottesville, USA ; Yan, Z., University of Virginia, Charlottesville, USA ; Yao, T.P., Duke University, Durham, USA

Molecules and Cells, 2015, 38(4), , pp.343-348 [Periódico revisado por pares]

United States: Korean Society for Molecular and Cellular Biology

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Título:
HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs
Autor: Cohen, T.J., Duke University, Durham, USA ; Choi, M.C., Duke University, Durham, USA ; Kapur, M., Duke University, Durham, USA ; Lira, V.A., University of Virginia, Charlottesville, USA ; Yan, Z., University of Virginia, Charlottesville, USA ; Yao, T.P., Duke University, Durham, USA
Assuntos: Animals ; Cell Line ; EXPRESION GENICA ; EXPRESSION DES GENES ; fiber type,HDAC4,MEF2,PGC-1alpha ; GENE EXPRESSION ; Gene Expression Regulation, Enzymologic ; Histone Deacetylases - biosynthesis ; Histone Deacetylases - genetics ; Mice ; Mice, Inbred C57BL ; Muscle Fibers, Skeletal - enzymology ; Muscle Fibers, Skeletal - physiology ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Phosphorylation ; Transcription Factors - metabolism ; Transcription, Genetic ; Transgenes ; 생물학
É parte de: Molecules and Cells, 2015, 38(4), , pp.343-348
Notas: A50
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
KISTI1.1003/JNL.JAKO201513251335060
These authors contributed equally to this work.
G704-000079.2015.38.4.005
Descrição: Fiber type-specific programs controlled by the transcription factor MEF2 dictate muscle functionality. Here, we show that HDAC4, a potent MEF2 inhibitor, is predominantly localized to the nuclei in fast/glycolytic fibers in contrast to the sarcoplasm in slow/oxidative fibers. The cytoplasmic localization is associated with HDAC4 hyper-phosphorylation in slow/oxidative-fibers. Genetic reprogramming of fast/glycolytic fibers to oxidative fibers by active CaMKII or calcineurin leads to increased HDAC4 phosphorylation, HDAC4 nuclear export, and an increase in markers associated with oxidative fibers. Indeed, HDAC4 represses the MEF2-dependent, PGC-1alpha-mediated oxidative metabolic gene program. Thus differential phosphorylation and localization of HDAC4 contributes to establishing fiber type-specific transcriptional programs.
Editor: United States: Korean Society for Molecular and Cellular Biology
Idioma: Inglês;Coreano

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HDAC4 Regulates Muscle Fiber Type-Specific Gene Expression Programs

Cohen, T.J., Duke University, Durham, USA ; Choi, M.C., Duke University, Durham, USA ; Kapur, M., Duke University, Durham, USA ; Lira, V.A., University of Virginia, Charlottesville, USA ; Yan, Z., University of Virginia, Charlottesville, USA ; Yao, T.P., Duke University, Durham, USA

United States: Korean Society for Molecular and Cellular Biology

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