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Barriers to the free diffusion of proteins and lipids in the plasma membrane

Trimble, William S ; Grinstein, Sergio

The Journal of cell biology, 2015-02, Vol.208 (3), p.259-271 [Periódico revisado por pares]

United States: Rockefeller University Press

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  • Título:
    Barriers to the free diffusion of proteins and lipids in the plasma membrane
  • Autor: Trimble, William S ; Grinstein, Sergio
  • Assuntos: Animals ; Cell Membrane - metabolism ; Cell Membrane - ultrastructure ; Cell Membrane Structures - metabolism ; Cells ; Cytokinesis ; Diffusion ; Humans ; Lipids ; Membrane Lipids - metabolism ; Membrane Proteins - metabolism ; Membranes ; Protein Transport ; Proteins ; Reviews
  • É parte de: The Journal of cell biology, 2015-02, Vol.208 (3), p.259-271
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Biological membranes segregate into specialized functional domains of distinct composition, which can persist for the entire life of the cell. How separation of their lipid and (glyco)protein components is generated and maintained is not well understood, but the existence of diffusional barriers has been proposed. Remarkably, the physical nature of such barriers and the manner whereby they impede the free diffusion of molecules in the plane of the membrane has rarely been studied in depth. Moreover, alternative mechanisms capable of generating membrane inhomogeneity are often disregarded. Here we describe prototypical biological systems where membrane segregation has been amply documented and discuss the role of diffusional barriers and other processes in the generation and maintenance of their structural and functional compartmentalization.
  • Editor: United States: Rockefeller University Press
  • Idioma: Inglês

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