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Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2)

Ababneh, M ; Götz, C ; Montenarh, M

Biochemical and biophysical research communications, 2001-05, Vol.283 (2), p.507-512 [Periódico revisado por pares]

United States

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Título:
Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2)
Autor: Ababneh, M ; Götz, C ; Montenarh, M
Assuntos: Animals ; cdc2 protein ; CDC2 Protein Kinase - antagonists & inhibitors ; CDC2 Protein Kinase - genetics ; CDC2 Protein Kinase - metabolism ; Cell Cycle ; Cell Line ; Down-Regulation ; Histones - metabolism ; Humans ; In Vitro Techniques ; Mutation ; p34 protein ; Peptide Fragments - genetics ; Peptide Fragments - metabolism ; Phosphorylation ; Recombinant Proteins - genetics ; Recombinant Proteins - metabolism ; Spodoptera ; Tumor Suppressor Protein p53 - genetics ; Tumor Suppressor Protein p53 - metabolism
É parte de: Biochemical and biophysical research communications, 2001-05, Vol.283 (2), p.507-512
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: We previously found that p53 binds to the catalytic subunit of the p34(cdc2)/cyclin B1-kinase. In the present study we analyzed the functional consequences of this interaction. Binding of wild-type p53 to p34(cdc2)/cyclin B1 results in a significant decrease of its histone H1 kinase activity. Binding of p53 to the kinase is a prerequisite for the inhibition because a mutant p53 which lacks the binding region fails to influence the enzymatic activity. Furthermore, by using C-terminal fragments of p53 it became obvious that also some other structural elements in the N-terminal region are necessary for the inhibitory effect. Our present study provides evidence that p53 might regulate cell-cycle checkpoints not only on the transcriptional level but also by binding to the cell-cycle regulating kinase p34(cdc2).
Editor: United States
Idioma: Inglês

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Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2)

Ababneh, M ; Götz, C ; Montenarh, M

United States

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