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Cloning, Chromosal Mapping, and Tissue Expression of the Gene Encoding the Human Eph-Family Kinase Ligand Ephrin-A2

Aasheim, Hans-Christian ; Pedeutour, Florence ; Grosgeorge, Josiane ; Logtenberg, Ton

Biochemical and biophysical research communications, 1998-11, Vol.252 (2), p.378-382 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Cloning, Chromosal Mapping, and Tissue Expression of the Gene Encoding the Human Eph-Family Kinase Ligand Ephrin-A2
Autor: Aasheim, Hans-Christian ; Pedeutour, Florence ; Grosgeorge, Josiane ; Logtenberg, Ton
Assuntos: Adult ; Amino Acid Sequence ; Animals ; Base Sequence ; Chromosome Mapping ; Chromosomes, Human, Pair 19 - genetics ; Cloning, Molecular ; DNA, Complementary - genetics ; Ephrin-A2 ; Fetus - metabolism ; Gene Expression Regulation, Developmental ; Humans ; Hybrid Cells ; In Situ Hybridization, Fluorescence ; Ligands ; Mice ; Molecular Sequence Data ; Receptor Protein-Tyrosine Kinases - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Sequence Homology, Amino Acid ; Species Specificity ; Tissue Distribution ; Transcription Factors - genetics ; Transcription Factors - metabolism
É parte de: Biochemical and biophysical research communications, 1998-11, Vol.252 (2), p.378-382
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The Eph-related receptor tyrosine kinases constitute a large family of receptors with most members displaying specific expression patterns in the developing embryo. Ligands for Eph receptor tyrosine kinases, recently renamed ephrins, comprise a family of at least 8 membrane-bound members that display promiscuous binding to Eph receptors. Here we report the characterization of a human cDNA clone with high homology to the gene encoding the murine ephrin-A2 ligand. The human gene encodes a single 2.4-kb mRNA with a restricted and developmentally-regulated tissue distribution pattern. In the fetus, ephrin-A2 mRNA is expressed in brain and intestine, whereas in the adult, high levels of ephrin-A2 mRNA are detectable in lung and intestine. Using PCR-based screening of genomic DNA from human x rodent hybrid cell lines, the gene encoding ephrin-A2 (EFNA2) was assigned to chromosome 19. Fluorescencein situhybridization to metaphase chromosome preparations refined this localization to band p13.3.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Cloning, Chromosal Mapping, and Tissue Expression of the Gene Encoding the Human Eph-Family Kinase Ligand Ephrin-A2

Aasheim, Hans-Christian ; Pedeutour, Florence ; Grosgeorge, Josiane ; Logtenberg, Ton

United States: Elsevier Inc

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