Idioma:

Antitumour Activity of the Microencapsulation of Annona vepretorum Essential Oil

Bomfim, Larissa M. ; Menezes, Leociley R. A. ; Rodrigues, Ana Carolina B. C. ; Dias, Rosane B. ; Gurgel Rocha, Clarissa A. ; Soares, Milena B. P. ; Neto, Albertino F. S. ; Nascimento, Magaly P. ; Campos, Adriana F. ; Silva, Lidércia C. R. C. e. ; Costa, Emmanoel V. ; Bezerra, Daniel P.

Basic & clinical pharmacology & toxicology, 2016-03, Vol.118 (3), p.208-213 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Antitumour Activity of the Microencapsulation of Annona vepretorum Essential Oil
Autor: Bomfim, Larissa M. ; Menezes, Leociley R. A. ; Rodrigues, Ana Carolina B. C. ; Dias, Rosane B. ; Gurgel Rocha, Clarissa A. ; Soares, Milena B. P. ; Neto, Albertino F. S. ; Nascimento, Magaly P. ; Campos, Adriana F. ; Silva, Lidércia C. R. C. e. ; Costa, Emmanoel V. ; Bezerra, Daniel P.
Assuntos: Adult ; Alkenes - pharmacology ; Animals ; Annona - chemistry ; Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - pharmacology ; beta-Cyclodextrins - pharmacology ; Cell Line, Tumor ; Cyclohexanones - pharmacology ; Disease Models, Animal ; Drug Compounding ; Gas Chromatography-Mass Spectrometry ; Hep G2 Cells ; Humans ; Inhibitory Concentration 50 ; Male ; Melanoma, Experimental - drug therapy ; Mice ; Mice, Inbred C57BL ; Monoterpenes - pharmacology ; Oils, Volatile - chemistry ; Oils, Volatile - pharmacology ; Plant Leaves - chemistry ; Sesquiterpenes - pharmacology ; Sesquiterpenes, Germacrane - pharmacology ; Terpenes - pharmacology ; Young Adult
É parte de: Basic & clinical pharmacology & toxicology, 2016-03, Vol.118 (3), p.208-213
Descrição: Annona vepretorum Mart. (Annonaceae), popularly known as ‘bruteira’, has nutritional and medicinal uses. This study investigated the chemical composition and antitumour potential of the essential oil of A. vepretorum leaf alone and complexed with β‐cyclodextrin in a microencapsulation. The essential oil was obtained by hydrodistillation using a Clevenger‐type apparatus and analysed using GC‐MS and GC‐FID. In vitro cytotoxicity of the essential oil and some of its major constituents in tumour cell lines from different histotypes was evaluated using the alamar blue assay. Furthermore, the in vivo efficacy of essential oil was demonstrated in mice inoculated with B16‐F10 mouse melanoma. The essential oil included bicyclogermacrene (35.71%), spathulenol (18.89%), (E)‐β‐ocimene (12.46%), α‐phellandrene (8.08%), o‐cymene (6.24%), germacrene D (3.27%) and α‐pinene (2.18%) as major constituents. The essential oil and spathulenol exhibited promising cytotoxicity. In vivo tumour growth was inhibited by the treatment with the essential oil (inhibition of 34.46%). Importantly, microencapsulation of the essential oil increased in vivo tumour growth inhibition (inhibition of 62.66%).
Editor: England: Wiley Subscription Services, Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 9 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Antitumour Activity of the Microencapsulation of Annona vepretorum Essential Oil

Bomfim, Larissa M. ; Menezes, Leociley R. A. ; Rodrigues, Ana Carolina B. C. ; Dias, Rosane B. ; Gurgel Rocha, Clarissa A. ; Soares, Milena B. P. ; Neto, Albertino F. S. ; Nascimento, Magaly P. ; Campos, Adriana F. ; Silva, Lidércia C. R. C. e. ; Costa, Emmanoel V. ; Bezerra, Daniel P.

England: Wiley Subscription Services, Inc

Buscando em bases de dados remotas. Favor aguardar.