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Pregnant Women with Endemic Pemphigus Foliaceus (Fogo Selvagem) Give Birth to Disease-Free Babies

Rocha-Alvarez, Rosicler ; Friedman, Horacio ; Campbell, Iphis T ; Souza-Aguiar, Ligia ; Martins-Castro, Raymundo ; Diaz, Luis A

Journal of investigative dermatology, 1992-07, Vol.99 (1), p.78-82 [Periódico revisado por pares]

MALDEN: Elsevier Inc

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Título:
Pregnant Women with Endemic Pemphigus Foliaceus (Fogo Selvagem) Give Birth to Disease-Free Babies
Autor: Rocha-Alvarez, Rosicler ; Friedman, Horacio ; Campbell, Iphis T ; Souza-Aguiar, Ligia ; Martins-Castro, Raymundo ; Diaz, Luis A
Assuntos: Adult ; Autoantibodies ; Autoantibodies - blood ; Autoimmune diseases ; Biological and medical sciences ; Biopsy ; Birth ; Brazil - epidemiology ; Bullous diseases of the skin ; Colombia - epidemiology ; Cord blood ; Dermatology ; Epidermis ; Female ; Humans ; Immunoglobulin G ; Infant, Newborn ; Life Sciences & Biomedicine ; Maternal-Fetal Exchange ; Medical sciences ; Monoclonal antibodies ; Neonates ; Pemphigus - complications ; Pemphigus - etiology ; Pemphigus - immunology ; Pemphigus foliaceus ; pemphigus vulgaris ; Placenta ; Pregnancy ; Pregnancy Complications - etiology ; Science & Technology ; Skin - immunology ; Skin - pathology ; Skin diseases
É parte de: Journal of investigative dermatology, 1992-07, Vol.99 (1), p.78-82
Notas: Medline
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Descrição: Endemic pemphigus foliaceus (PF), also known as Fogo Selvagem (FS), is an organ-specific autoimmune disease mediated by autoantibodies. These autoantibodies are disease specific, predominantly restricted to the IgG4 subclass, and pathogenic, as demonstrated by passive transfer studies. In contrast to pemphigus vulgaris, neonatal skin disease does not appear to occur in babies born to mothers with non-endemic PF or FS. In the present study we have examined 19 mother/neonate pairs where the mother had documented FS. Mothers and neonates were examined soon after delivery and tested by immunofluorescent (IF) techniques for ES autoantibodies either in circulation (mothers' sera or babies' cord blood) or bound to the neonatal epidermis. All neonates included in this study were born with normal skin. Twelve biopsies from 17 neonates showed negative direct IF using both FITC-antihuman IgG or monoclonal anti-IgG subclass antibodies. In five biopsies the epidermal ICS of the babies showed weak staining. In 10 of the 19 cord sera tested, FS IgG autoantibodies were undetectable; in nine, these autoantibodies were present in low titers (< 1: 40). The sera of the mothers showed higher titers of FS autoantibodies, and IgG4 was the predominant IgG subclass autoantibodies. It appears that human placenta may modulate the expression of disease in the newborn by operating as a “biologic immunoadsorbent” of pathogenic autoantibodies.
Editor: MALDEN: Elsevier Inc
Idioma: Inglês

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Pregnant Women with Endemic Pemphigus Foliaceus (Fogo Selvagem) Give Birth to Disease-Free Babies

Rocha-Alvarez, Rosicler ; Friedman, Horacio ; Campbell, Iphis T ; Souza-Aguiar, Ligia ; Martins-Castro, Raymundo ; Diaz, Luis A

MALDEN: Elsevier Inc

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