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Past Medical History and Pancreatic Cancer Risk: Results From a Multicenter Case-Control Study

Maisonneuve, Patrick, Eng ; Lowenfels, Albert B., MD ; Bueno-de-Mesquita, H. Bas, MD, MPH, PhD ; Ghadirian, Parviz, PhD ; Baghurst, Peter A., BAgSc, BSc, MSc, PhD ; Zatonski, Witold A., MD, ScD ; Miller, Anthony B., MD ; Duell, Eric J., PhD ; Boffetta, Paolo, PhD ; Boyle, Peter, PhD

Annals of epidemiology, 2010-02, Vol.20 (2), p.92-98 [Revista revisada por pares]

United States: Elsevier Inc

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Past Medical History and Pancreatic Cancer Risk: Results From a Multicenter Case-Control Study
Autor: Maisonneuve, Patrick, Eng ; Lowenfels, Albert B., MD ; Bueno-de-Mesquita, H. Bas, MD, MPH, PhD ; Ghadirian, Parviz, PhD ; Baghurst, Peter A., BAgSc, BSc, MSc, PhD ; Zatonski, Witold A., MD, ScD ; Miller, Anthony B., MD ; Duell, Eric J., PhD ; Boffetta, Paolo, PhD ; Boyle, Peter, PhD
Materias: Adult ; Aged ; Aged, 80 and over ; Allergies ; Australia - epidemiology ; Canada - epidemiology ; Case-Control Studies ; Diabetes ; Diabetes Mellitus - epidemiology ; Female ; Humans ; Internal Medicine ; Male ; Middle Aged ; Multicenter Case-Control Study ; Netherlands - epidemiology ; Pancreas Cancer ; Pancreatic Neoplasms - epidemiology ; Pancreatitis ; Pancreatitis - epidemiology ; Past Medical History ; Poland - epidemiology ; Risk Factors ; Smoking - epidemiology
Es parte de: Annals of epidemiology, 2010-02, Vol.20 (2), p.92-98
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descripción: Purpose To investigate risk factors that may be linked to pancreatic cancer. Methods We designed a multicenter population-based case–control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland. Results After adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23 − 9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18 − 74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60 − 2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56 − 12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50 − 0.82). Conclusions Patients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancreatic cancer.
Editor: United States: Elsevier Inc
Idioma: Inglés

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Past Medical History and Pancreatic Cancer Risk: Results From a Multicenter Case-Control Study

Maisonneuve, Patrick, Eng ; Lowenfels, Albert B., MD ; Bueno-de-Mesquita, H. Bas, MD, MPH, PhD ; Ghadirian, Parviz, PhD ; Baghurst, Peter A., BAgSc, BSc, MSc, PhD ; Zatonski, Witold A., MD, ScD ; Miller, Anthony B., MD ; Duell, Eric J., PhD ; Boffetta, Paolo, PhD ; Boyle, Peter, PhD

United States: Elsevier Inc

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