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Seroprevalence and Determinants of Helicobacter pylori Infection in the Hispanic Community Health Study/Study of Latinos

Tsang, Sabrina H. ; Avilés-Santa, M. Larissa ; Abnet, Christian C. ; Brito, Maximo O. ; Daviglus, Martha L. ; Wassertheil-Smoller, Sylvia ; Castañeda, Sheila F. ; Minnerath, Sharon ; Talavera, Gregory A. ; Graubard, Barry I. ; Thyagarajan, Bharat ; Camargo, M. Constanza

Clinical gastroenterology and hepatology, 2022-03, Vol.20 (3), p.e438-e451 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Seroprevalence and Determinants of Helicobacter pylori Infection in the Hispanic Community Health Study/Study of Latinos
  • Autor: Tsang, Sabrina H. ; Avilés-Santa, M. Larissa ; Abnet, Christian C. ; Brito, Maximo O. ; Daviglus, Martha L. ; Wassertheil-Smoller, Sylvia ; Castañeda, Sheila F. ; Minnerath, Sharon ; Talavera, Gregory A. ; Graubard, Barry I. ; Thyagarajan, Bharat ; Camargo, M. Constanza
  • Assuntos: Adolescent ; Adult ; Aged ; Determinants ; HCHS/SOL ; Helicobacter Infections - epidemiology ; Helicobacter pylori ; Hispanic or Latino ; Hispanics/Latinos ; Humans ; Male ; Middle Aged ; Prevalence ; Public Health ; Risk Factors ; Seroepidemiologic Studies ; Seroprevalence ; United States - epidemiology ; Young Adult
  • É parte de: Clinical gastroenterology and hepatology, 2022-03, Vol.20 (3), p.e438-e451
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Acquisition of data: LA-S, MLD, SW-S, SM, GAT, BT
    Obtained funding: CCA, BT, MCC
    Statistical analysis: SHT, BIG, MCC
    Drafting of the manuscript: SHT, MCC
    Study supervision: BT, MCC
    Study concept and design: LA-S, CCA, BT, MCC
    Analysis and interpretation of data: SHT, LA-S, CCA, SM, BIG, BT, MCC
    Authors' Contributions
    Critical revision of the manuscript for important intellectual content: All authors
  • Descrição: Helicobacter pylori infection is the primary known risk factor for gastric cancer. Despite the global decline in H. pylori prevalence, this infection remains a major public health concern in developing areas, including Latin America. Our study aimed to determine H. pylori seroprevalence and identified its determinants among Hispanics/Latinos living in the United States (U.S.). The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a population-based sample of self-identified Hispanics/Latinos (n = 16,144) in four U.S. communities, aged 18 to 74 years, recruited from randomly selected households using a stratified two-stage area probability sample design based on sampling households within sampled census block groups weighted for differential response rates. Anti-H. pylori immunoglobulin G antibodies were measured by an enzyme-linked immunosorbent assay using plasma samples. We calculated adjusted seroprevalence (i.e., predicted margins) from multivariable logistic regression models. The overall weighted H. pylori seroprevalence was 57% among HCHS/SOL participants, with 38% and 62% seropositivity among U.S.-born and non-U.S.-born individuals, respectively. Age-adjusted prevalence varied by self-reported Hispanic/Latino background, ranging from 47% in Puerto Rican to 72% in Central American backgrounds. Adjusted H. pylori seroprevalence was higher in the following groups: older age, male sex, lower education, non-U.S. born status, smoking, greater number of missing teeth, fewer doctor visits, lower ferritin level, and hepatitis A seropositivity. H. pylori seroprevalence in Hispanics/Latinos remains high and differed significantly by Hispanic/Latino background. H. pylori seropositivity is strongly associated with poor socioeconomic conditions. These findings highlight the ongoing importance of this bacterial infection in the U.S.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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