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Long-term effect of Helicobacter pylori eradication on plasma homocysteine in elderly patients with cobalamin deficiency

Marino, Marília Campos Abreu ; de Oliveira, Celso Affonso ; Rocha, Andreia Maria Camargos ; Rocha, Gifone Aguiar ; Clementino, Nelma Cristina Diogo ; Antunes, Leonardo França ; Oliveira, Ricardo Araújo ; Martins, Almir Sousa ; Del Puerto, Helen Lima ; D’Almeida, Vânia ; Galdieri, Luciano ; Pedroso, Ênio Roberto Pietra ; Cabral, Mônica Maria Demas Álvares ; Nogueira, Ana Margarida Miguel Ferreira ; Queiroz, Dulciene Maria Magalhães

Gut, 2007-04, Vol.56 (4), p.469-474 [Periódico revisado por pares]

London: BMJ Publishing Group Ltd and British Society of Gastroenterology

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Título:
Long-term effect of Helicobacter pylori eradication on plasma homocysteine in elderly patients with cobalamin deficiency
Autor: Marino, Marília Campos Abreu ; de Oliveira, Celso Affonso ; Rocha, Andreia Maria Camargos ; Rocha, Gifone Aguiar ; Clementino, Nelma Cristina Diogo ; Antunes, Leonardo França ; Oliveira, Ricardo Araújo ; Martins, Almir Sousa ; Del Puerto, Helen Lima ; D’Almeida, Vânia ; Galdieri, Luciano ; Pedroso, Ênio Roberto Pietra ; Cabral, Mônica Maria Demas Álvares ; Nogueira, Ana Margarida Miguel Ferreira ; Queiroz, Dulciene Maria Magalhães
Assuntos: 13C-UBT ; 13C-urea breath test ; Aged ; Aged, 80 and over ; Autoantibodies - blood ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; CFU ; cobalamin ; colony forming units ; delta over baseline ; DOB ; elderly ; Female ; Follow-Up Studies ; Gastrins - blood ; Gastritis - blood ; Gastritis - drug therapy ; Gastritis - microbiology ; Gastritis - pathology ; Health risk assessment ; Helicobacter Infections - blood ; Helicobacter Infections - complications ; Helicobacter Infections - drug therapy ; Helicobacter Infections - pathology ; Helicobacter Pylori ; Homocysteine - blood ; Human bacterial diseases ; Humans ; hyperhomocysteinaemia ; Infectious diseases ; Intrinsic Factor - immunology ; Male ; MCV ; mean corpuscular volume ; Medical sciences ; Middle Aged ; Neurology ; Parietal Cells, Gastric - immunology ; Pepsinogen A - blood ; Plasma ; Prospective Studies ; Ulcers ; Vascular diseases and vascular malformations of the nervous system ; Vitamin B 12 Deficiency - blood ; Vitamin B 12 Deficiency - microbiology ; Vitamin deficiency
É parte de: Gut, 2007-04, Vol.56 (4), p.469-474
Notas: istex:7B00F5C9A22A0184FF584F1B9A4DBA32BD4B6A06
PMID:17005765
local:0560469
Correspondence to:  Dulciene Maria Magalhães Queiroz  Laboratory of Research in Bacteriology; Faculdade de Medicina, Av. Alfredo Balena, 190/4026-30130-100, Belo Horizonte, MG, Brazil; dqueiroz@medicina.ufmg.br
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Descrição: Background:Helicobacter pylori gastritis may lead to impairment of the production of pepsinogen and acid, which are essential to cobalamin absorption. In turn, cobalamin deficiency leads to hyperhomocysteinaemia, a risk factor for cardio and cerebrovascular diseases. Aim: To evaluate the effect of H pylori eradication on plasma homocysteine levels in elderly patients. Patients: Sixty-two H pylori-positive elderly patients with cobalamin deficiency were prospectively studied. Methods: Homocysteine and cobalamin concentrations were determined before, 6 and 12 months after H pylori eradication. Results: Corpus atrophy was observed in a few patients; otherwise, in most of them, the degree of corpus gastritis was moderate to severe. The initial homocysteine mean (SD) levels decreased from 41.0 (27.1) to 21.6 (10.1) μmol/l at the 6 month follow-up (p<0.001) and to 13.1 (3.8) μmol/l 12 months after H pylori eradication (p<0.001). Conversely, initial cobalamin mean levels increased from 145.5 (48.7) pmol/l to 209.8 (87.1) pmol/l and to 271.2 (140.8) pmol/l, 6 and 12 months after treatment, respectively (p<0.001 for both). Although the erythrocyte mean corpuscular volume was within reference intervals, it decreased significantly 6 (p = 0.002) and 12 (p<0.001) months after treatment. Conclusions: The results of the current study demonstrated that the eradication of H pylori in elderly patients with cobalamin deficiency is followed by increasing of cobalamin and decreasing of homocysteine blood levels.
Editor: London: BMJ Publishing Group Ltd and British Society of Gastroenterology
Idioma: Inglês

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Long-term effect of Helicobacter pylori eradication on plasma homocysteine in elderly patients with cobalamin deficiency

London: BMJ Publishing Group Ltd and British Society of Gastroenterology

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