Idioma:

Distribution of Locoregional Breast Cancer Recurrence in Relation to Postoperative Radiation Fields and Biological Subtypes

Adra, Jamila ; Lundstedt, Dan ; Killander, Fredrika ; Holmberg, Erik ; Haghanegi, Mahnaz ; Kjellén, Elisabeth ; Karlsson, Per ; Alkner, Sara

International journal of radiation oncology, biology, physics, 2019-10, Vol.105 (2), p.285-295 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Distribution of Locoregional Breast Cancer Recurrence in Relation to Postoperative Radiation Fields and Biological Subtypes
Autor: Adra, Jamila ; Lundstedt, Dan ; Killander, Fredrika ; Holmberg, Erik ; Haghanegi, Mahnaz ; Kjellén, Elisabeth ; Karlsson, Per ; Alkner, Sara
Assuntos: Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms - chemistry ; Breast Neoplasms - epidemiology ; Breast Neoplasms - radiotherapy ; Breast Neoplasms - surgery ; Cancer and Oncology ; Cancer och onkologi ; Clinical Medicine ; Female ; Humans ; Incidence ; Klinisk medicin ; Mastectomy ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Middle Aged ; Neoplasm Recurrence, Local - chemistry ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Recurrence, Local - pathology ; Postoperative Care ; Practice Guidelines as Topic ; Radiologi och bildbehandling ; Radiology, Nuclear Medicine and Medical Imaging ; Receptor, ErbB-2 ; Receptors, Estrogen ; Receptors, Progesterone ; Retrospective Studies ; Sweden - epidemiology ; Time Factors
É parte de: International journal of radiation oncology, biology, physics, 2019-10, Vol.105 (2), p.285-295
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research
Descrição: To investigate incidence and location of locoregional recurrence (LRR) in patients who have received postoperative locoregional radiation therapy (LRRT) for primary breast cancer. LRR-position in relation to applied radiotherapy and the primary tumor biological subtype were analyzed with the aim of evaluating current target guidelines and radiation therapy techniques in relation to tumor biology. Medical records were reviewed for all patients who received postoperative LRRT for primary breast cancer in southwestern Sweden from 2004 to 2008 (N = 923). Patients with LRR as a first event were identified (n = 57; distant failure and death were considered competing risks). Computed tomographic images identifying LRR were used to compare LRR locations with postoperative LRRT fields. LRR risk and distribution were then related to the primary breast cancer biologic subtype and to current target guidelines. Cumulative LRR incidence after 10 years was 7.1% (95% confidence interval [CI], 5.5-9.1). Fifty-seven of the 923 patients in the cohort developed LRR (30 local recurrences and 30 regional recurrences, of which 3 cases were simultaneous local and regional recurrence). Most cases of LRR developed fully (56%) or partially (26%) within postoperatively irradiated areas. The most common location for out-of-field regional recurrence was cranial to radiation therapy fields in the supraclavicular fossa. Patients with an estrogen receptor negative (ER–) (hazard ratio [HR], 4.6; P < .001; 95% CI, 2.5-8.4) or HER2+ (HR, 2.4; P = .007; 95% CI, 1.3-4.7) primary breast cancer presented higher risks of LRR compared with those with ER+ tumors. ER-/HER2+ tumors more frequently recurred in-field (68%) rather than marginally or out-of-field (32%). In addition, 75% of in-field recurrences derived from an ER- or HER+ tumor, compared with 45% of marginal or out-of-field recurrences. A complete pathologic response in the axilla after neoadjuvant treatment was associated with a lower degree of LRR risk (P = .022). Incidence and location of LRR seem to be related to the primary breast cancer biologic subtype. Individualized LRRT according to tumor biology may be applied to improve outcomes.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 9 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Distribution of Locoregional Breast Cancer Recurrence in Relation to Postoperative Radiation Fields and Biological Subtypes

Adra, Jamila ; Lundstedt, Dan ; Killander, Fredrika ; Holmberg, Erik ; Haghanegi, Mahnaz ; Kjellén, Elisabeth ; Karlsson, Per ; Alkner, Sara

United States: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.