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Analytical and clinical performance of molecular assay used by the Brazilian public laboratory network to detect and discriminate Zika, Dengue and Chikungunya viruses in blood

Ribeiro, Marisa O. ; Godoy, Daniela T. ; Fontana-Maurell, Marcela ; Costa, Elaine M. ; Andrade, Elisabete F. ; Rocha, Daniele R. ; Ferreira, Antônio G.P. ; Brindeiro, Rodrigo ; Tanuri, Amilcar ; Alvarez, Patrícia

The Brazilian journal of infectious diseases, 2021-03, Vol.25 (2), p.101542-101542, Article 101542 [Periódico revisado por pares]

Brazil: Elsevier España, S.L.U

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Analytical and clinical performance of molecular assay used by the Brazilian public laboratory network to detect and discriminate Zika, Dengue and Chikungunya viruses in blood
Autor: Ribeiro, Marisa O. ; Godoy, Daniela T. ; Fontana-Maurell, Marcela ; Costa, Elaine M. ; Andrade, Elisabete F. ; Rocha, Daniele R. ; Ferreira, Antônio G.P. ; Brindeiro, Rodrigo ; Tanuri, Amilcar ; Alvarez, Patrícia
Assuntos: Arboviruses ; Biochemical assays ; Blood ; Chikungunya ; Chikungunya fever ; Dengue ; Diagnosis ; INFECTIOUS DISEASES ; Medical examination ; Molecular detection ; Molecular diagnostic techniques ; Original ; Public health ; Real time RT-PCR ; Zika
É parte de: The Brazilian journal of infectious diseases, 2021-03, Vol.25 (2), p.101542-101542, Article 101542
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: In response to the Zika epidemics in Brazil, the ZDC molecular assay (Bio-Manguinhos) was developed and registered at the Brazilian Regulatory Agency of Health Surveillance - ANVISA. The circulation of Zika (ZIKV) Dengue (DENV) and Chikungunya (CHIKV) viruses and their clinical similarities are challenges to correctly diagnose these viruses. The simultaneous detection of ZIKV, DENV and CHIKV is an important tool for diagnosis and surveillance. Here, we present the analytical and clinical performance evaluation of ZDC molecular assay (Bio-Manguinhos) at the public health laboratories three years after its registration at ANVISA. The clinical performance demonstrates the ZDC molecular assay (Bio-Manguinhos) has 100% sensitivity and 100% specificity to detect and discriminate ZIKV, CHIKV, and DENV from clinical plasma samples. The ZDC molecular assay (Bio-Manguinhos) results were highly reproducible and no cross-reactivity was seen during testing with a panel of other infectious agents. In conclusion, the ZDC molecular assay (Bio-Manguinhos) is an accurate and reliable tool to monitor Zika, dengue and chikungunya infections in countries like Brazil with simultaneous circulation of the three viruses.
Editor: Brazil: Elsevier España, S.L.U
Idioma: Inglês;Português

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Analytical and clinical performance of molecular assay used by the Brazilian public laboratory network to detect and discriminate Zika, Dengue and Chikungunya viruses in blood

Ribeiro, Marisa O. ; Godoy, Daniela T. ; Fontana-Maurell, Marcela ; Costa, Elaine M. ; Andrade, Elisabete F. ; Rocha, Daniele R. ; Ferreira, Antônio G.P. ; Brindeiro, Rodrigo ; Tanuri, Amilcar ; Alvarez, Patrícia

Brazil: Elsevier España, S.L.U

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