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Preventive effect of polypropylene mesh bonded norvancomycin slow-release microsphere on Staphylococcus aureus infection of incisional hernia repair model

Liu, Feide ; Gao, Lili ; Liu, Tianjun ; Li, Jiye ; Yao, Sheng ; Wang, Shibing ; Zhu, Yingmei ; Pei, Lijuan

Zhongguo xiu fu chong jian wai ke za zhi, 2011-05, Vol.25 (5), p.582-586 [Periódico revisado por pares]

China

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Título:
Preventive effect of polypropylene mesh bonded norvancomycin slow-release microsphere on Staphylococcus aureus infection of incisional hernia repair model
Autor: Liu, Feide ; Gao, Lili ; Liu, Tianjun ; Li, Jiye ; Yao, Sheng ; Wang, Shibing ; Zhu, Yingmei ; Pei, Lijuan
Assuntos: Animals ; Delayed-Action Preparations - administration & dosage ; Delayed-Action Preparations - therapeutic use ; Herniorrhaphy ; Male ; Microspheres ; Rats ; Rats, Sprague-Dawley ; Staphylococcal Infections - prevention & control ; Surgical Mesh ; Surgical Wound Infection - prevention & control ; Vancomycin - administration & dosage ; Vancomycin - analogs & derivatives ; Vancomycin - therapeutic use
É parte de: Zhongguo xiu fu chong jian wai ke za zhi, 2011-05, Vol.25 (5), p.582-586
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Mesh infection may occur after incisional hernia repair using prosthetic mesh. Preparation of antibiotics-bonded meshes to prevent infection is one of the solutions. To evaluate the anti-infection effect of polypropylene mesh bonded norvancomycin slow-release microsphere by preparing the rat model of incisional hernia repair contaminated with Staphylococcus aureus. The norvancomycin slow-release microspheres were prepared by emulsion and solvent evaporation method and they were bonded to polypropylene mesh (50 mg/mesh). The appearance of the microspheres was observed using scanning electronic microscope (SEM). The content of norvancomycin in microspheres and the release rate of the norvancomycin in norvancomycin-bonded polypropylene mesh were detected using high performance liquid chromatography method. The rat models of incisional hernia were developed in 40 healthy Sprague Dawley rats, aged 10-11 weeks and weighing 200-250 g. The rats were divided randomly into the experimental group (norvancomycin-bonded p
Editor: China
Idioma: Chinês

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Preventive effect of polypropylene mesh bonded norvancomycin slow-release microsphere on Staphylococcus aureus infection of incisional hernia repair model

Liu, Feide ; Gao, Lili ; Liu, Tianjun ; Li, Jiye ; Yao, Sheng ; Wang, Shibing ; Zhu, Yingmei ; Pei, Lijuan

China

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