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In vivo experimental study on antibacterial and osteogenic capabilities of hydroxyapatite antimicrobial coating with silver

Ruan, Hongjiang ; Fan, Cunyi ; Liu, Shenghe ; Zheng, Xuebin

Zhongguo xiu fu chong jian wai ke za zhi, 2011-06, Vol.25 (6), p.668-672 [Periódico revisado por pares]

China

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  • Título:
    In vivo experimental study on antibacterial and osteogenic capabilities of hydroxyapatite antimicrobial coating with silver
  • Autor: Ruan, Hongjiang ; Fan, Cunyi ; Liu, Shenghe ; Zheng, Xuebin
  • Assuntos: Animals ; Anti-Bacterial Agents - pharmacology ; Bone Screws ; Dogs ; Drug Carriers ; Durapatite - pharmacology ; External Fixators ; Male ; Materials Testing ; Osteogenesis - drug effects ; Silver Compounds - pharmacology ; Staphylococcus aureus
  • É parte de: Zhongguo xiu fu chong jian wai ke za zhi, 2011-06, Vol.25 (6), p.668-672
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    content type line 23
  • Descrição: To investigate the antibacterial and osteogenic capabilities in vivo of hydroxyapatite (HA)/silver (Ag) coating. HA/Ag coating (Ag quality percentage was 3%) and HA coating were deposited to external fixator Schanz screws. The tibial fracture model was established in right hindlimb of 18 adult male Beagle dogs (weighing 15-20 kg). The tibia was stabilized with an external fixator and 2 Schanz screws of HA coating at proximal tibia (control group, n = 18) and HA/Ag coating at distal tibia (experimental group, n = 18), and every screw incision was infected with Staphylococcus aureus. Infection in screw holes and the changes of bone-screw interface were observed by wound grading and X-ray films. In control group, wounds infection became worse with time (chi2 = 13.492, P = 0.001), while in experimental group, no obvious change was observed chi2X = 0.208, P = 0.901). The wound grading of experimental group was significantly better than that of the control group at 1, 2, and 3 weeks (P < 0.05). Laser scanning confo
  • Editor: China
  • Idioma: Chinês
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