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Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases

Zorzi, D. ; Laurent, A. ; Pawlik, T. M. ; Lauwers, G. Y. ; Vauthey, J.-N. ; Abdalla, E. K.

British journal of surgery, 2007-03, Vol.94 (3), p.274-286 [Periódico revisado por pares]

Chichester, UK: John Wiley & Sons, Ltd

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Título:
Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases
Autor: Zorzi, D. ; Laurent, A. ; Pawlik, T. M. ; Lauwers, G. Y. ; Vauthey, J.-N. ; Abdalla, E. K.
Assuntos: Antineoplastic Agents - adverse effects ; Biological and medical sciences ; Chemotherapy, Adjuvant - adverse effects ; Colorectal Neoplasms ; Fatty Liver - chemically induced ; Fatty Liver - pathology ; General aspects ; Hepatectomy ; Hepatic Veno-Occlusive Disease - chemically induced ; Hepatic Veno-Occlusive Disease - pathology ; Humans ; Liver - drug effects ; Liver Neoplasms - mortality ; Liver Neoplasms - secondary ; Liver Neoplasms - therapy ; Medical sciences ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system
É parte de: British journal of surgery, 2007-03, Vol.94 (3), p.274-286
Notas: istex:FDB2D482185A99BB6C6B18390241A6D4B9EC355C
ark:/67375/WNG-VHK0TB22-4
ArticleID:BJS5719
Descrição: Background: Preoperative systemic chemotherapy is increasingly used in patients who undergo hepatic resection for colorectal liver metastases (CLM). Although chemotherapy‐related hepatic injury has been reported, the incidence and the effect of such injury on patient outcome remain ill defined. Methods: A systematic review of relevant studies published before May 2006 was performed. Studies that reported on liver injury associated with preoperative chemotherapy for CLM were identified and data on chemotherapy‐specific liver injury and patient outcome following hepatic resection were synthesized and tabulated. Results: Hepatic steatosis, a mild manifestation of non‐alcoholic fatty liver disease (NAFLD), may occur after treatment with 5‐fluorouracil and is associated with increased postoperative morbidity. Non‐alcoholic steatohepatitis, a serious complication of NAFLD that includes inflammation and hepatocyte damage, can occur after treatment with irinotecan, especially in obese patients. Irinotecan‐associated steatohepatitis can affect hepatic reserve and increase morbidity and mortality after hepatectomy. Hepatic sinusoidal obstruction syndrome can occur in patients treated with oxaliplatin, but does not appear to be associated with an increased risk of perioperative death. Conclusion: Preoperative chemotherapy for CLM induces regimen‐specific hepatic changes that can affect patient outcome. Both response rate and toxicity should be considered when selecting preoperative chemotherapy in patients with CLM. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Hepatotoxicity may compromise outcome
Editor: Chichester, UK: John Wiley & Sons, Ltd
Idioma: Inglês

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Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases

Zorzi, D. ; Laurent, A. ; Pawlik, T. M. ; Lauwers, G. Y. ; Vauthey, J.-N. ; Abdalla, E. K.

Chichester, UK: John Wiley & Sons, Ltd

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