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High-Intensity Extended Swimming Exercise Reduces Pain-Related Behavior in Mice: Involvement of Endogenous Opioids and the Serotonergic System

Mazzardo-Martins, Leidiane ; Martins, Daniel F ; Marcon, Rodrigo ; dos Santos, Ubirajara D ; Speckhann, Breno ; Gadotti, Vinícius M ; Sigwalt, André Roberto ; Guglielmo, Luiz Guilherme A ; Santos, Adair Roberto Soares

The journal of pain, 2010-12, Vol.11 (12), p.1384-1393 [Periódico revisado por pares]

United States: Elsevier Inc

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High-Intensity Extended Swimming Exercise Reduces Pain-Related Behavior in Mice: Involvement of Endogenous Opioids and the Serotonergic System
Autor: Mazzardo-Martins, Leidiane ; Martins, Daniel F ; Marcon, Rodrigo ; dos Santos, Ubirajara D ; Speckhann, Breno ; Gadotti, Vinícius M ; Sigwalt, André Roberto ; Guglielmo, Luiz Guilherme A ; Santos, Adair Roberto Soares
Assuntos: Acetic Acid - toxicity ; Anesthesia & Perioperative Care ; Animals ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Fenclonine - analogs & derivatives ; Fenclonine - pharmacology ; Irritants - toxicity ; Male ; Mice ; mouse ; Naloxone - pharmacology ; Narcotic Antagonists - pharmacology ; nociception ; opioid ; Opioid Peptides - metabolism ; Pain - chemically induced ; Pain - metabolism ; Pain - physiopathology ; Pain Medicine ; Pain Threshold - drug effects ; Pain Threshold - physiology ; Physical exercise ; serotonin ; Serotonin - metabolism ; Swimming - physiology
É parte de: The journal of pain, 2010-12, Vol.11 (12), p.1384-1393
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SourceType-Scholarly Journals-1
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Descrição: Abstract The present study examined the hyponociceptive effect of swimming exercise in a chemical behavioral model of nociception and the mechanisms involved in this effect. Male mice were submitted to swimming sessions (30 min/d for 5 days). Twenty-four hours after the last session, we noticed that swimming exercise decreased the number of abdominal constriction responses caused by acetic acid compared with the nonexercised group. The hyponociception caused by exercise in the acetic acid test was significantly attenuated by intraperitoneal (i.p.) pretreatment of mice with naloxone (a nonselective opioid receptor antagonist, 1 mg/kg), ρ-chlorophenylalanine methyl ester (PCPA, an inhibitor of serotonin synthesis, 100 mg/kg once a day for 4 consecutive days), and by bilateral adrenalectomy. Collectively, the present results provide experimental evidences indicating for the first time that high-intensity extended swimming exercise reduces pain-related behavior in mice. The mechanisms involve an interaction with opioid and serotonin systems. Furthermore, endogenous opioids released by adrenal glands probably are involved in this effect. Perspective Our results indicate that high-intensity extended exercise endogenously controls acute pain by activation of opioidergic and serotonergic pathways. Furthermore, these results support the use of exercise as a nonpharmacological approach for the management of acute pain.
Editor: United States: Elsevier Inc
Idioma: Inglês

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High-Intensity Extended Swimming Exercise Reduces Pain-Related Behavior in Mice: Involvement of Endogenous Opioids and the Serotonergic System

Mazzardo-Martins, Leidiane ; Martins, Daniel F ; Marcon, Rodrigo ; dos Santos, Ubirajara D ; Speckhann, Breno ; Gadotti, Vinícius M ; Sigwalt, André Roberto ; Guglielmo, Luiz Guilherme A ; Santos, Adair Roberto Soares

United States: Elsevier Inc

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