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USP6 -induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis

Oliveira, André M., MD, PhD ; Chou, Margaret M., PhD

Human pathology, 2014, Vol.45 (1), p.1-11 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
USP6 -induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis
Autor: Oliveira, André M., MD, PhD ; Chou, Margaret M., PhD
Assuntos: Aneurysmal bone cyst ; Bone cancer ; Bone Cysts, Aneurysmal - genetics ; Bone Cysts, Aneurysmal - pathology ; Cysts ; Fasciitis - genetics ; Fasciitis - pathology ; Humans ; Nodular fasciitis ; Oncogenes ; Pathology ; Proto-Oncogene Proteins - genetics ; Transient neoplasia ; Tumors ; Ubiquitin Thiolesterase - genetics ; USP6
É parte de: Human pathology, 2014, Vol.45 (1), p.1-11
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Summary USP6 (also known as TRE17) is a ubiquitin-specific protease that was identified as an oncogene in transfection experiments with Ewing sarcoma DNA 2 decades ago. Until recently, little was known about USP6 function and mechanisms of oncogenic activation. The identification of USP6 fusion genes in aneurysmal bone cyst (ABC) and, more recently, in nodular fasciitis led to a better understanding of the pathogenesis of these lesions. Furthermore, the detection of USP6 genomic rearrangements or USP6 fusion genes may be used as a diagnostic tool for these lesions. In this review, we discuss the clinicopathologic features, molecular pathology, and pathogenesis of ABC and nodular fasciitis. We also discuss the possible line of differentiation of ABC and its relationship to nodular fasciitis and other lesions.
Editor: United States: Elsevier Inc
Idioma: Inglês

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USP6 -induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular fasciitis

Oliveira, André M., MD, PhD ; Chou, Margaret M., PhD

United States: Elsevier Inc

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