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Systematic review with meta‐analysis: neuroimaging in hepatitis C chronic infection

Oriolo, G. ; Egmond, E. ; Mariño, Z. ; Cavero, M. ; Navines, R. ; Zamarrenho, L. ; Solà, R. ; Pujol, J. ; Bargallo, N. ; Forns, X. ; Martin‐Santos, R.

Alimentary pharmacology & therapeutics, 2018-05, Vol.47 (9), p.1238-1252 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

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  • Título:
    Systematic review with meta‐analysis: neuroimaging in hepatitis C chronic infection
  • Autor: Oriolo, G. ; Egmond, E. ; Mariño, Z. ; Cavero, M. ; Navines, R. ; Zamarrenho, L. ; Solà, R. ; Pujol, J. ; Bargallo, N. ; Forns, X. ; Martin‐Santos, R.
  • Assuntos: Basal ganglia ; Brain ; Central nervous system ; Choline ; Chronic infection ; Cirrhosis ; Cognition ; Computed tomography ; Cortex ; Creatine ; Emission analysis ; Encephalopathy ; Fatigue ; Glutamine ; Hepatitis ; Hepatitis C ; Image processing ; Interferon ; Liver ; Liver cirrhosis ; Liver diseases ; Magnetic resonance imaging ; Magnetic resonance spectroscopy ; Medical imaging ; Mental depression ; Meta-analysis ; Neural networks ; Neuroimaging ; Neurology ; Patients ; Perfusion ; Positron emission tomography ; Resonance ; Spectroscopic analysis ; Spectroscopy ; Spectrum analysis ; Substantia alba ; Systematic review ; Viruses
  • É parte de: Alimentary pharmacology & therapeutics, 2018-05, Vol.47 (9), p.1238-1252
  • Notas: Funding information
    Fondo de Investigación en Salud. Instituto de Salud Carlos III, Grant/Award Number: FIS: PI10/01827; Fondos FEDER, Grant/Award Number: PI15/00151; Ajuts per el support a grups de recerca (SGR), Grant/Award Number: 2014_SGR_605; Gilead Fellowship Program, Grant/Award Number: GLD17/00273.
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  • Descrição: Summary Background Chronic hepatitis C is considered a systemic disease because of extra‐hepatic manifestations. Neuroimaging has been employed in hepatitis C virus‐infected patients to find in vivo evidence of central nervous system alterations. Aims Systematic review and meta‐analysis of neuroimaging research in chronic hepatitis C treatment naive patients, or patients previously treated without sustained viral response, to study structural and functional brain impact of hepatitis C. Methods Using PRISMA guidelines a database search was conducted from inception up until 1 May 2017 for peer‐reviewed studies on structural or functional neuroimaging assessment of chronic hepatitis C patients without cirrhosis or encephalopathy, with control group. Meta‐analyses were performed when possible. Results The final sample comprised 25 studies (magnetic resonance spectroscopy [N = 12], perfusion weighted imaging [N = 1], positron emission tomography [N = 3], single‐photon emission computed tomography [N = 4], functional connectivity in resting state [N = 1], diffusion tensor imaging [N = 2] and structural magnetic resonance imaging [N = 2]). The whole sample was of 509 chronic hepatitis C patients, with an average age of 41.5 years old and mild liver disease. A meta‐analysis of magnetic resonance spectroscopy studies showed increased levels of choline/creatine ratio (mean difference [MD] 0.12, 95% confidence interval [CI] 0.06‐0.18), creatine (MD 0.85, 95% CI 0.42‐1.27) and glutamate plus glutamine (MD 1.67, 95% CI 0.39‐2.96) in basal ganglia and increased levels of choline/creatine ratio in centrum semiovale white matter (MD 0.13, 95% CI 0.07‐0.19) in chronic hepatitis C patients compared with healthy controls. Photon emission tomography studies meta‐analyses did not find significant differences in PK11195 binding potential in cortical and subcortical regions of chronic hepatitis C patients compared with controls. Correlations were observed between various neuroimaging alterations and neurocognitive impairment, fatigue and depressive symptoms in some studies. Conclusions Patients with chronic hepatitis C exhibit cerebral metabolite alterations and structural or functional neuroimaging abnormalities, which sustain the hypothesis of hepatitis C virus involvement in brain disturbances.
  • Editor: England: Wiley Subscription Services, Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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