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Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches

Soto-Angona, Óscar ; Anmella, Gerard ; Valdés-Florido, María José ; De Uribe-Viloria, Nieves ; Carvalho, Andre F ; Penninx, Brenda W J H ; Berk, Michael

BMC medicine, 2020-10, Vol.18 (1), p.261-14, Article 261 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches
Autor: Soto-Angona, Óscar ; Anmella, Gerard ; Valdés-Florido, María José ; De Uribe-Viloria, Nieves ; Carvalho, Andre F ; Penninx, Brenda W J H ; Berk, Michael
Assuntos: Anxiety ; Cirrhosis ; Comorbidity ; Complex systems ; Development and progression ; Driving ability ; Environmental risk ; Fatty liver ; Health aspects ; Humans ; Life expectancy ; Life span ; Liver ; Liver cirrhosis ; Liver diseases ; Mental disorders ; Mental Disorders - etiology ; Mental Disorders - psychology ; Mental illness ; Mentally ill ; Mentally ill persons ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - psychology ; Mitochondria ; Mortality ; Non-alcoholic fatty liver disease ; Non-alcoholic Fatty Liver Disease - complications ; Non-alcoholic Fatty Liver Disease - physiopathology ; Non-alcoholic Fatty Liver Disease - psychology ; Non-alcoholic steatohepatitis ; Non-communicable disorders ; Oxidative Stress ; Parenchyma ; Pathogenesis ; Psychiatry ; Quality of life ; Quality of Life - psychology ; Review ; Steatosis
É parte de: BMC medicine, 2020-10, Vol.18 (1), p.261-14, Article 261
Descrição: Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in over 5% of the parenchyma in the absence of excessive alcohol consumption. It is more prevalent in patients with diverse mental disorders, being part of the comorbidity driving loss of life expectancy and quality of life, yet remains a neglected entity. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and increases the risk for cirrhosis and hepatic carcinoma. Both NAFLD and mental disorders share pathophysiological pathways, and also present a complex, bidirectional relationship with the metabolic syndrome (MetS) and related cardiometabolic diseases. This review compares the demographic data on NAFLD and NASH among the global population and the psychiatric population, finding differences that suggest a higher incidence of this disease among the latter. It also analyzes the link between NAFLD and psychiatric disorders, looking into common pathophysiological pathways, such as metabolic, genetic, and lifestyle factors. Finally, possible treatments, tailored approaches, and future research directions are suggested. NAFLD is part of a complex system of mental and non-communicable somatic disorders with a common pathogenesis, based on shared lifestyle and environmental risks, mediated by dysregulation of inflammation, oxidative stress pathways, and mitochondrial function. The recognition of the prevalent comorbidity between NAFLD and mental disorders is required to inform clinical practice and develop novel interventions to prevent and treat these complex and interacting disorders.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches

Soto-Angona, Óscar ; Anmella, Gerard ; Valdés-Florido, María José ; De Uribe-Viloria, Nieves ; Carvalho, Andre F ; Penninx, Brenda W J H ; Berk, Michael

England: BioMed Central Ltd

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