Idioma:

New N-(benzhydryloxyalkyl)-4-(carboxy/carbamoylmethyl) piperidine derivatives with antidepressant activity

El Ahmad, Y ; Maillet, P ; Laurent, E ; Talab, A ; Teste, JF ; Cédat, MJ ; Fiez-Vandal, PY ; Dokhan, R ; Ollivier, R

European journal of medicinal chemistry, 1997, Vol.32 (3), p.205-218 [Periódico revisado por pares]

Oxford: Elsevier Masson SAS

Texto completo disponível

Citações Citado por

Enviar para

Título:
New N-(benzhydryloxyalkyl)-4-(carboxy/carbamoylmethyl) piperidine derivatives with antidepressant activity
Autor: El Ahmad, Y ; Maillet, P ; Laurent, E ; Talab, A ; Teste, JF ; Cédat, MJ ; Fiez-Vandal, PY ; Dokhan, R ; Ollivier, R
Assuntos: 3-alkylpiperidine ; antidepressant activity ; benzhydryloxyalkyl ; Biological and medical sciences ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; uptake inhibitor
É parte de: European journal of medicinal chemistry, 1997, Vol.32 (3), p.205-218
Descrição: Several benzhydryloxylalkylpiperidine derivatives were prepared with the aim of obtaining new antidepressant compounds. The influence of the length of the aliphatic chain and of aromatic and piperidine ring substitutions was studied. The pharmacological activity of compounds was investigated in vivo by means of a screening comprising four pharmacological tests: antagonism of reserpine and apomorphine hypothermia; increase of yohimbine induced mortality; and antagonism of immobility in tail suspension test. An in-depth pharmacological study was performed with the more active compounds and a binding study to serotonin (5-HT), norepinephrine (NE) and dopamine (DA) reuptake sites was performed for the preferred compounds. The most active compounds [+], [−]- cis- 31, 32 and 46 exhibited an interesting psychopharmacological profile after intraperitoneal administration. This profile was confirmed by the oral route for 31 and 46. In vitro, these compounds showed a non-selective inhibition of DA, NE and 5-HT uptake.
Editor: Oxford: Elsevier Masson SAS
Idioma: Inglês

Links

View record in Pascal Francis

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

New N-(benzhydryloxyalkyl)-4-(carboxy/carbamoylmethyl) piperidine derivatives with antidepressant activity

El Ahmad, Y ; Maillet, P ; Laurent, E ; Talab, A ; Teste, JF ; Cédat, MJ ; Fiez-Vandal, PY ; Dokhan, R ; Ollivier, R

Oxford: Elsevier Masson SAS

Buscando em bases de dados remotas. Favor aguardar.