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Barefoot Plantar Pressure Indicates Progressive Neurological Damage in Patients with Human T-Cell Lymphotropic Virus Type 1 Infection

Vasconcelos, Beatriz Helena B ; Souza, Givago S ; Barroso, Tatiana G C P ; Silveira, Luiz Carlos L ; Sousa, Rita Catarina M ; Callegari, Bianca ; Xavier, Marília B Switzer, William M.

PloS one, 2016-03, Vol.11 (3), p.e0151855-e0151855 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Barefoot Plantar Pressure Indicates Progressive Neurological Damage in Patients with Human T-Cell Lymphotropic Virus Type 1 Infection
Autor: Vasconcelos, Beatriz Helena B ; Souza, Givago S ; Barroso, Tatiana G C P ; Silveira, Luiz Carlos L ; Sousa, Rita Catarina M ; Callegari, Bianca ; Xavier, Marília B
Switzer, William M.
Assuntos: Accidental falls ; Adult ; Biology and life sciences ; Blood & organ donations ; Body weight ; Care and treatment ; Central nervous system diseases ; Comparative analysis ; Complications and side effects ; Diagnosis ; Disease ; Disturbances ; Falling ; Falls (Accidents) ; Feet ; Female ; Foot - physiopathology ; Health aspects ; Health sciences ; HTLV-I Infections - complications ; HTLV-I Infections - physiopathology ; HTLV-I Infections - virology ; Human T-lymphotropic virus 1 - physiology ; Humans ; Infection ; Infections ; Lymphocytes T ; Male ; Medicine and Health Sciences ; Middle Aged ; Neurological complications ; Paraparesis, Tropical spastic ; Patients ; Physiology ; Plantar pressure ; Posture ; Pressure ; Pressure distribution ; Reflexes ; Risk factors ; Sensitivity ; Skin ; Spastic paraparesis ; Spinal cord ; Stress concentration ; T cells ; Tactile ; Trauma, Nervous System - complications ; Trauma, Nervous System - pathology ; Trauma, Nervous System - physiopathology ; Trauma, Nervous System - virology ; Tropical spastic paraparesis ; Viruses
É parte de: PloS one, 2016-03, Vol.11 (3), p.e0151855-e0151855
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Conceived and designed the experiments: RCMS GSS BC MBX. Performed the experiments: BHBV TGCPB. Analyzed the data: BHBV GSS TGCPB RCMS MBX. Contributed reagents/materials/analysis tools: BC GSS. Wrote the paper: BHBV GSS TGCPB LCLS RCMS BC MBX.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: The human T-Cell Lymphotropic Virus Type 1 (HTLV-1) is a retrovirus associated with neurological alterations; individuals with HTLV-1 infection may develop HTLV-1 associated myelopathy / tropical spastic paraparesis (HAM/TSP). Frequent neurological complaints include foot numbness and leg weakness. In this study, we compared the distribution of the body weight on different areas of the foot in HTLV-1 patients with HAM/TSP, asymptomatic HTLV-1 patients, and healthy individuals. We studied 36 HTLV-1 infected patients, who were divided in two groups of 18 patients each based on whether or not they had been diagnosed with HAM/TSP, and 17 control subjects. The evaluation included an interview on the patient's clinical history and examinations of the patient's reflexes, foot skin tactile sensitivity, and risk of falling. The pressure distribution on different areas of the foot was measured with baropodometry, using a pressure platform, while the patients had their eyes open or closed. The prevalence of neurological disturbances-altered reflexes and skin tactile sensitivity and increased risk of falling-was higher in HTLV-1 HAM/TSP patients than in HTLV-1 asymptomatic patients. The medium and maximum pressure values were higher in the forefoot than in the midfoot and hindfoot in both HTLV-1 groups. In addition, the pressure on the hindfoot was lower in HAM/TSP patients compared to control subjects. The neurological disturbances associated with HTLV-1 infection gradually worsened from HTLV-1 asymptomatic patients to HAM/TSP patients. Baropodometry is a valuable tool to establish the extent of neurological damage in patients suffering from HTLV-1 infection.
Editor: United States: Public Library of Science
Idioma: Inglês

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Barefoot Plantar Pressure Indicates Progressive Neurological Damage in Patients with Human T-Cell Lymphotropic Virus Type 1 Infection

Vasconcelos, Beatriz Helena B ; Souza, Givago S ; Barroso, Tatiana G C P ; Silveira, Luiz Carlos L ; Sousa, Rita Catarina M ; Callegari, Bianca ; Xavier, Marília B Switzer, William M.

United States: Public Library of Science

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