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Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network

Puig-Barberà, Joan ; Natividad-Sancho, Angels ; Trushakova, Svetlana ; Sominina, Anna ; Pisareva, Maria ; Ciblak, Meral A ; Badur, Selim ; Yu, Hongjie ; Cowling, Benjamin J ; El Guerche-Séblain, Clotilde ; Mira-Iglesias, Ainara ; Kisteneva, Lidiya ; Stolyarov, Kirill ; Yurtcu, Kubra ; Feng, Luzhao ; López-Labrador, Xavier ; Burtseva, Elena Bauch, Chris T.

PloS one, 2016-05, Vol.11 (5), p.e0154970-e0154970 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network
Autor: Puig-Barberà, Joan ; Natividad-Sancho, Angels ; Trushakova, Svetlana ; Sominina, Anna ; Pisareva, Maria ; Ciblak, Meral A ; Badur, Selim ; Yu, Hongjie ; Cowling, Benjamin J ; El Guerche-Séblain, Clotilde ; Mira-Iglesias, Ainara ; Kisteneva, Lidiya ; Stolyarov, Kirill ; Yurtcu, Kubra ; Feng, Luzhao ; López-Labrador, Xavier ; Burtseva, Elena
Bauch, Chris T.
Assuntos: Admission and discharge ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis ; Asthma ; Biology and life sciences ; Cardiovascular diseases ; Care and treatment ; Child ; Child, Preschool ; China ; Cluster Analysis ; Comorbidity ; Complications ; Confidence intervals ; Demographic aspects ; Disease control ; Disease prevention ; Epidemiological Monitoring ; Epidemiology ; Ethics ; Female ; Health aspects ; Health surveillance ; Hospital admission and discharge ; Hospitalization ; Hospitals ; Humans ; Illnesses ; Immunosuppression ; Infant ; Infant, Newborn ; Infections ; Infectious diseases ; Influenza ; Influenza virus ; Influenza, Human - epidemiology ; Laboratories ; Liver ; Liver diseases ; Male ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Multivariate Analysis ; Northern Hemisphere ; Odds Ratio ; Orthomyxoviridae ; Outcome Assessment (Health Care) ; Patient Admission ; Patients ; People and Places ; Pregnancy ; Pregnancy complications ; Pregnancy Complications, Infectious ; Prospective Studies ; Public health ; Regression analysis ; Risk ; Risk analysis ; Risk Factors ; Risk reduction ; Russia ; Seasons ; Spain ; Statistical analysis ; Studies ; Surveillance ; Turkey ; Vaccination ; Virology ; Viruses ; Womens health ; Young Adult
É parte de: PloS one, 2016-05, Vol.11 (5), p.e0154970-e0154970
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Competing Interests: The authors have read the journal’s policy and have the following conflicts: JPB, ANS and AMI work for the Vaccines Research Area of FISABIO, which has received funding from GlaxoSmithKline, Novartis, Pfizer, Sanofi Pasteur, and Sanofi Pasteur-MSD for conducting studies on infectious disease epidemiology, vaccine effectiveness, pharmacoeconomics, and safety. The Vaccines Research Area is and has been involved in various randomized clinical trials with GlaxoSmithKline, Novartis, Pfizer, and MSD vaccines. CES is employed by Sanofi Pasteur. BJC has received research funding from MedImmune Inc. and Sanofi Pasteur, and consults for Crucell NV. Finally, the authors confirm that their competing interests, as previously stated, do not alter their adherence to PLOS ONE policies on sharing data and materials. All other authors declare no conflicts of interest. The authors confirm that they do not have any patents relating to material pertinent to this article.
Conceived and designed the experiments: JPB AS MP MAC HY EB SB BJC CEGS. Performed the experiments: JPB ST AS MP MAC AMI LK KS HY BJC KY LF XLL EB. Analyzed the data: JPB ANS AMI XLL. Contributed reagents/materials/analysis tools: XLL. Wrote the paper: JPB ANS. Read, had the opportunity to comment, and approved the manuscript: SB BJC CEGS XLL.
Complete membership of the Global Influenza Hospital Surveillance Study Group (GIHSN) is listed in the Acknowledgments.
Descrição: The Global Influenza Hospital Surveillance Network was established in 2012 to obtain valid epidemiologic data on hospital admissions with influenza-like illness. Here we describe the epidemiology of admissions with influenza within the Northern Hemisphere sites during the 2013/2014 influenza season, identify risk factors for severe outcomes and complications, and assess the impact of different influenza viruses on clinically relevant outcomes in at-risk populations. Eligible consecutive admissions were screened for inclusion at 19 hospitals in Russia, Turkey, China, and Spain using a prospective, active surveillance approach. Patients that fulfilled a common case definition were enrolled and epidemiological data were collected. Risk factors for hospitalization with laboratory-confirmed influenza were identified by multivariable logistic regression. 5303 of 9507 consecutive admissions were included in the analysis. Of these, 1086 were influenza positive (534 A(H3N2), 362 A(H1N1), 130 B/Yamagata lineage, 3 B/Victoria lineage, 40 untyped A, and 18 untyped B). The risk of hospitalization with influenza (adjusted odds ratio [95% confidence interval]) was elevated for patients with cardiovascular disease (1.63 [1.33-2.02]), asthma (2.25 [1.67-3.03]), immunosuppression (2.25 [1.23-4.11]), renal disease (2.11 [1.48-3.01]), liver disease (1.94 [1.18-3.19], autoimmune disease (2.97 [1.58-5.59]), and pregnancy (3.84 [2.48-5.94]). Patients without comorbidities accounted for 60% of admissions with influenza. The need for intensive care or in-hospital death was not significantly different between patients with or without influenza. Influenza vaccination was associated with a lower risk of confirmed influenza (adjusted odds ratio = 0.61 [0.48-0.77]). Influenza infection was detected among hospital admissions with and without known risk factors. Pregnancy and underlying comorbidity increased the risk of detecting influenza virus in patients hospitalized with influenza-like illness. Our results support influenza vaccination as a measure for reducing the risk of influenza-associated hospital admission.
Editor: United States: Public Library of Science
Idioma: Inglês

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Epidemiology of Hospital Admissions with Influenza during the 2013/2014 Northern Hemisphere Influenza Season: Results from the Global Influenza Hospital Surveillance Network

United States: Public Library of Science

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