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Functional homotopic changes in multiple sclerosis with resting-state functional MR imaging

Zhou, Yongxia ; Milham, M ; Zuo, X-N ; Kelly, C ; Jaggi, H ; Herbert, J ; Grossman, R I ; Ge, Y

American journal of neuroradiology : AJNR, 2013-06, Vol.34 (6), p.1180-1187 [Periódico revisado por pares]

United States: American Society of Neuroradiology

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Título:
Functional homotopic changes in multiple sclerosis with resting-state functional MR imaging
Autor: Zhou, Yongxia ; Milham, M ; Zuo, X-N ; Kelly, C ; Jaggi, H ; Herbert, J ; Grossman, R I ; Ge, Y
Assuntos: Adult ; Cerebellum - pathology ; Cerebellum - physiopathology ; Cerebral Cortex - pathology ; Cerebral Cortex - physiopathology ; Disability Evaluation ; Female ; Functional ; Globus Pallidus - pathology ; Globus Pallidus - physiopathology ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Motor Cortex - pathology ; Motor Cortex - physiopathology ; Multiple Sclerosis, Relapsing-Remitting - pathology ; Multiple Sclerosis, Relapsing-Remitting - physiopathology ; Pilot Projects ; Somatosensory Cortex - pathology ; Somatosensory Cortex - physiopathology ; Thalamus - pathology ; Thalamus - physiopathology ; Visual Cortex - pathology ; Visual Cortex - physiopathology
É parte de: American journal of neuroradiology : AJNR, 2013-06, Vol.34 (6), p.1180-1187
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: CC is extensively involved in MS with interhemispheric dysfunction. The purpose of this study was to determine whether interhemispheric correlation is altered in MS by use of a recently developed RS-fMRI homotopy technique and whether these homotopic changes correlate with CC pathology. Twenty-four patients with relapsing-remitting MS and 24 age-matched healthy volunteers were studied with RS-fMRI and DTI acquired at 3T. The Pearson correlation of each pair of symmetric interhemispheric voxels of RS-fMRI time-series data was performed to compute VMHC, and z-transformed for subsequent group-level analysis. In addition, 5 CC segments in the midsagittal area and DTI-derived FA were measured to quantify interhemispheric microstructural changes and correlate with global and regional VMHC in MS. Relative to control participants, patients with MS exhibited an abnormal homotopic pattern with decreased VMHC in the primary visual, somatosensory, and motor cortices and increased VMHC in several regions associated with sensory processing and motor control including the insula, thalamus, pallidum, and cerebellum. The global VMHC correlates moderately with the average FA of the entire CC for all participants in both groups (r = 0.3; P = .03). Our data provide preliminary evidence of the potential usefulness of VMHC analyses for the detection of abnormalities of interhemispheric coordination in MS. We demonstrated that the whole-brain homotopic RS-fMRI pattern was altered in patients with MS, which was partially associated with the underlying structural degenerative changes of CC measured with FA.
Editor: United States: American Society of Neuroradiology
Idioma: Inglês

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Functional homotopic changes in multiple sclerosis with resting-state functional MR imaging

Zhou, Yongxia ; Milham, M ; Zuo, X-N ; Kelly, C ; Jaggi, H ; Herbert, J ; Grossman, R I ; Ge, Y

United States: American Society of Neuroradiology

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