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Superiority of Deformable Image Co-registration in the Integration of Diagnostic Positron Emission Tomography-Computed Tomography to the Radiotherapy Treatment Planning Pathway for Oesophageal Carcinoma

Ward, G ; Ramasamy, S ; Sykes, J.R ; Prestwich, R ; Chowdhury, F ; Scarsbrook, A ; Murray, P ; Harris, K ; Crellin, A ; Hatfield, P ; Sebag-Montefiore, D ; Spezi, E ; Crosby, T ; Radhakrishna, G

Clinical oncology (Royal College of Radiologists (Great Britain)), 2016-10, Vol.28 (10), p.655-662 [Periódico revisado por pares]

England: Elsevier Ltd

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  • Título:
    Superiority of Deformable Image Co-registration in the Integration of Diagnostic Positron Emission Tomography-Computed Tomography to the Radiotherapy Treatment Planning Pathway for Oesophageal Carcinoma
  • Autor: Ward, G ; Ramasamy, S ; Sykes, J.R ; Prestwich, R ; Chowdhury, F ; Scarsbrook, A ; Murray, P ; Harris, K ; Crellin, A ; Hatfield, P ; Sebag-Montefiore, D ; Spezi, E ; Crosby, T ; Radhakrishna, G
  • Assuntos: Aged ; Aged, 80 and over ; Deformable image registration ; Esophageal Neoplasms - diagnostic imaging ; Esophageal Neoplasms - radiotherapy ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Male ; Middle Aged ; oesophageal cancer ; pattern of local recurrence ; PET-CT imaging ; Positron Emission Tomography Computed Tomography - methods ; Radiology ; Radiometry - methods ; Radiotherapy Planning, Computer-Assisted - methods ; Retrospective Studies ; Tomography, X-Ray Computed - methods
  • É parte de: Clinical oncology (Royal College of Radiologists (Great Britain)), 2016-10, Vol.28 (10), p.655-662
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Abstract Aims To investigate the use of image co-registration in incorporating diagnostic positron emission tomography-computed tomography (PET-CT) directly into the radiotherapy treatment planning pathway, and to describe the pattern of local recurrence relative to the PET-avid volume. Materials and methods Fourteen patients were retrospectively identified, six of whom had local recurrence. The accuracy of deformable image registration (DIR) and rigid registration of the diagnostic PET-CT and recurrence CT, to the planning CT, were quantitatively assessed by comparing co-registration of oesophagus, trachea and aorta contours. DIR was used to examine the correlation between PET-avid volumes, dosimetry and site of recurrence. Results Positional metrics including the dice similarity coefficient (DSC) and conformity index (CI), showed DIR to be superior to rigid registration in the co-registration of diagnostic and recurrence imaging to the planning CT. For diagnostic PET-CT, DIR was superior to rigid registration in the transfer of oesophagus (DSC = 0.75 versus 0.65, P < 0.009 and CI = 0.59 versus 0.48, P < 0.003), trachea (DSC = 0.88 versus 0.65, P < 0.004 and CI = 0.78 versus 0.51, P < 0.0001) and aorta structures (DSC = 0.93 versus 0.86, P < 0.006 and CI = 0.86 versus 0.76, P < 0.006). For recurrence imaging, DIR was superior to rigid registration in the transfer of trachea (DSC = 0.91 versus 0.66, P < 0.03 and CI = 0.83 versus 0.51, P < 0.02) and oesophagus structures (DSC = 0.74 versus 0.51, P < 0.004 and CI = 0.61 versus 0.37, P < 0.006) with a non-significant trend for the aorta (DSC = 0.91 versus 0.75, P < 0.08 and CI = 0.83 versus 0.63, P < 0.06) structure. A mean inclusivity index of 0.93 (range 0.79–1) showed that the relapse volume was within the planning target volume (PTVPET-CT ); all relapses occurred within the high dose region. Conclusion DIR is superior to rigid registration in the co-registration of PET-CT and recurrence CT to the planning CT, and can be considered in the direct integration of PET-CT to the treatment planning process. Local recurrences occur within the PTVPET-CT , suggesting that this is a suitable target for dose-escalation strategies.
  • Editor: England: Elsevier Ltd
  • Idioma: Inglês
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