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Early Stage Nasopharyngeal Carcinoma: Radiotherapy Dose and Time Factors in Tumor Control

Chang, Joseph T ; See, Lai-Chu ; Liao, Chun-Ta ; Chen, Li-Hui ; Leung, Wai Man ; Chen, Shang-Wen ; Chen, Weng-Cheng

Japanese journal of clinical oncology, 1998-03, Vol.28 (3), p.207-213 [Periódico revisado por pares]

England: Foundation for Promotion of Cancer Research

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Título:
Early Stage Nasopharyngeal Carcinoma: Radiotherapy Dose and Time Factors in Tumor Control
Autor: Chang, Joseph T ; See, Lai-Chu ; Liao, Chun-Ta ; Chen, Li-Hui ; Leung, Wai Man ; Chen, Shang-Wen ; Chen, Weng-Cheng
Assuntos: Adult ; Aged ; Brachytherapy ; Carcinoma - mortality ; Carcinoma - pathology ; Carcinoma - radiotherapy ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - radiotherapy ; Disease-Free Survival ; early stage nasophaiyngeal carcinoma ; Female ; Humans ; intracavitaiy brachytherapy ; Male ; Middle Aged ; Nasopharyngeal Neoplasms - mortality ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - radiotherapy ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Radiotherapy Dosage ; Retrospective Studies ; Time Factors ; total radiation dose ; treatment time
É parte de: Japanese journal of clinical oncology, 1998-03, Vol.28 (3), p.207-213
Notas: ark:/67375/HXZ-JXC11TBZ-4
istex:EDCA57A2BD96C5D31B08137F1772BDF4AAB4CBD7
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Objective: To evaluate radiotherapy dose and length of treatment in the control of early stage nasopharyngeal carcinoma (NPC) treated with a combination of external radiotherapy and brachytherapy, Materials & Methods: We reviewed the records of 133 patients with early stage nasopharyngeal carcinoma (stage I or II, AJC/UICC staging system) who received definitive radiotherapy in Chang Gung Memorial Hospital from 1979 to 1991. The median follow-up time was 7.1 years with a minimum of 2 years. All patients were treated with megavoltage external radiotherapy to the nasopharynx area (63–72 Gy) followed by high dose rate intracavitary brachytherapy (5–16.5 Gy in one to three fractions, spaced 1–2 weeks apart). The median total dose and time of irradiation was 75 Gy (69.8–81.4 Gy) and 11.6 weeks (7.8–20 weeks) respectively. Survival analysis was used to examine the effect of several variables on prognosis. Results: The 5-year rates were 86.4% for local control, 84.7% for disease free survival, 88.5% for actuarial survival and 84.2% for overall survival. The treatment group (combination of time and dose of irradiation) was the most important prognostic factor according to Cox's proportional hazard model. Patients receiving radiation at a total dose of ≤75 Gy completed in <12 weeks showed the best prognosis. Conclusion: Treatment time and total treatment dose are both important factors in treating early stage NPC. Decreasing the total radiation time to <12 weeks and not exceeding a radiation dose of 75 Gy gave the best results.
Editor: England: Foundation for Promotion of Cancer Research
Idioma: Inglês

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Early Stage Nasopharyngeal Carcinoma: Radiotherapy Dose and Time Factors in Tumor Control

Chang, Joseph T ; See, Lai-Chu ; Liao, Chun-Ta ; Chen, Li-Hui ; Leung, Wai Man ; Chen, Shang-Wen ; Chen, Weng-Cheng

England: Foundation for Promotion of Cancer Research

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