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In vivo and in vitro estrogenic activity of the antidepressant fluoxetine

Müller, Juliane C. ; Imazaki, Pedro H. ; Boareto, Ana C. ; Lourenço, Emerson L.B. ; Golin, Munisa ; Vechi, Marina F. ; Lombardi, Natália F. ; Minatovicz, Bruna C. ; Scippo, Marie-Louise ; Martino-Andrade, Anderson J. ; Dalsenter, Paulo R.

Reproductive toxicology (Elmsford, N.Y.), 2012-08, Vol.34 (1), p.80-85 [Periódico revisado por pares]

Amsterdam: Elsevier Inc

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Título:
In vivo and in vitro estrogenic activity of the antidepressant fluoxetine
Autor: Müller, Juliane C. ; Imazaki, Pedro H. ; Boareto, Ana C. ; Lourenço, Emerson L.B. ; Golin, Munisa ; Vechi, Marina F. ; Lombardi, Natália F. ; Minatovicz, Bruna C. ; Scippo, Marie-Louise ; Martino-Andrade, Anderson J. ; Dalsenter, Paulo R.
Assuntos: Adult and adolescent clinical studies ; Animals ; Antidepressants ; Antidepressive Agents, Second-Generation - toxicity ; Biological and medical sciences ; Breast cancer ; Cell Line, Tumor ; Depression ; Drugs ; Embryology: invertebrates and vertebrates. Teratology ; Endocrine disruption ; Estradiol ; Estrogenic activity ; Estrogens, Non-Steroidal - toxicity ; Female ; Fluoxetine ; Fluoxetine - toxicity ; Fundamental and applied biological sciences. Psychology ; Genitalia, Male - anatomy & histology ; Genitalia, Male - drug effects ; Hershberger assay ; Humans ; Life sciences ; Male ; Medical sciences ; Mood disorders ; Organ Size - drug effects ; Pregnancy ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Rats ; Rats, Wistar ; Receptors, Estrogen - metabolism ; Reporter gene ; Reporter gene assay ; Sciences du vivant ; Teratology. Teratogens ; Toxicology ; Uterotrophic assay ; Uterus ; Uterus - drug effects ; Uterus - pathology
É parte de: Reproductive toxicology (Elmsford, N.Y.), 2012-08, Vol.34 (1), p.80-85
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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scopus-id:2-s2.0-84861688839
Descrição: ► A possible estrogenic action of fluoxetine is suggested. ► (Anti)estrogenic and (anti)androgenic activities of fluoxetine were investigated. ► Uterotrophic and gene reporter assays indicated a estrogenic activity of fluoxetine. ► Lack of androgenic or anti-androgenic activity of fluoxetine by Hershberger assay. Recent years have seen an increase in the use of antidepressant drugs, especially fluoxetine (FLX), in sensitive populations, such as pregnant and lactating women. Although some evidence suggests a possible endocrine action of FLX, no specific studies have been performed to investigate this hypothesis. In the present study, we investigated the possible (anti)androgenic and (anti)estrogenic actions of FLX using Hershberger, uterotrophic (0.4, 1.7, and 17mg/kg), and reporter gene (7.6–129μM) assays. In the Hershberger assay, no differences were observed in androgen-dependent organ weights. However, the uterotrophic and gene reporter assays indicated a possible estrogenic action of FLX. Uterine weight increased in the 1.7 and 17mg/kg/day groups in the 3-day uterotrophic assay in immature rats. Additionally, noncytotoxic concentrations of FLX induced estrogenic responses and increased the estrogenic response of estradiol in MCF-7 breast cancer cells transfected with luciferase.
Editor: Amsterdam: Elsevier Inc
Idioma: Inglês

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In vivo and in vitro estrogenic activity of the antidepressant fluoxetine

Müller, Juliane C. ; Imazaki, Pedro H. ; Boareto, Ana C. ; Lourenço, Emerson L.B. ; Golin, Munisa ; Vechi, Marina F. ; Lombardi, Natália F. ; Minatovicz, Bruna C. ; Scippo, Marie-Louise ; Martino-Andrade, Anderson J. ; Dalsenter, Paulo R.

Amsterdam: Elsevier Inc

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