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Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients

Zhang, Xu-Chao ; Wang, Jun ; Shao, Guo-Guang ; Wang, Qun ; Qu, Xiaotao ; Wang, Bo ; Moy, Christopher ; Fan, Yue ; Albertyn, Zayed ; Huang, Xiayu ; Zhang, Jingyu ; Qiu, Yang ; Platero, Suso ; Lorenzi, Matthew V ; Zudaire, Enrique ; Yang, Jennifer ; Cheng, Ying ; Xu, Lin ; Wu, Yi-Long

Nature communications, 2019-04, Vol.10 (1), p.1772-1772, Article 1772 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients
Autor: Zhang, Xu-Chao ; Wang, Jun ; Shao, Guo-Guang ; Wang, Qun ; Qu, Xiaotao ; Wang, Bo ; Moy, Christopher ; Fan, Yue ; Albertyn, Zayed ; Huang, Xiayu ; Zhang, Jingyu ; Qiu, Yang ; Platero, Suso ; Lorenzi, Matthew V ; Zudaire, Enrique ; Yang, Jennifer ; Cheng, Ying ; Xu, Lin ; Wu, Yi-Long
Assuntos: 1-Phosphatidylinositol 3-kinase ; Adenocarcinoma ; Adenocarcinoma of Lung - genetics ; Adenocarcinoma of Lung - immunology ; Adenocarcinoma of Lung - mortality ; Aged ; Antigen presentation ; Antigen Presentation - genetics ; Antigen Presentation - immunology ; Asian Continental Ancestry Group - genetics ; Cancer ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - immunology ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - mortality ; Cell survival ; Cytotoxicity ; Datasets as Topic ; Epidermal growth factor receptors ; ErbB Receptors - genetics ; Female ; Genomics ; Humans ; Immune system ; Immunology ; Infiltration ; Lung cancer ; Lung Neoplasms - genetics ; Lung Neoplasms - immunology ; Lymphocytes ; Lymphocytes T ; Lymphocytes, Tumor-Infiltrating - immunology ; Male ; Metastases ; Middle Aged ; Mutation ; Non-small cell lung carcinoma ; Patients ; Proto-Oncogene Proteins p21(ras) - genetics ; Signatures ; Squamous cell carcinoma ; T-Lymphocytes, Cytotoxic - immunology ; Wnt protein ; Wnt Signaling Pathway - genetics ; Wnt Signaling Pathway - immunology
É parte de: Nature communications, 2019-04, Vol.10 (1), p.1772-1772, Article 1772
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Deep understanding of the genomic and immunological differences between Chinese and Western lung cancer patients is of great importance for target therapy selection and development for Chinese patients. Here we report an extensive molecular and immune profiling study of 245 Chinese patients with non-small cell lung cancer. Tumor-infiltrating lymphocyte estimated using immune cell signatures is found to be significantly higher in adenocarcinoma (ADC, 72.5%) compared with squamous cell carcinoma (SQCC, 54.4%). The correlation of genomic alterations with immune signatures reveals that low immune infiltration was associated with EGFR mutations in ADC samples, PI3K and/or WNT pathway activation in SQCC. While KRAS mutations are found to be significantly associated with T cell infiltration in ADC samples. The SQCC patients with high antigen presentation machinery and cytotoxic T cell signature scores are found to have a prolonged overall survival time.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Comprehensive genomic and immunological characterization of Chinese non-small cell lung cancer patients

Zhang, Xu-Chao ; Wang, Jun ; Shao, Guo-Guang ; Wang, Qun ; Qu, Xiaotao ; Wang, Bo ; Moy, Christopher ; Fan, Yue ; Albertyn, Zayed ; Huang, Xiayu ; Zhang, Jingyu ; Qiu, Yang ; Platero, Suso ; Lorenzi, Matthew V ; Zudaire, Enrique ; Yang, Jennifer ; Cheng, Ying ; Xu, Lin ; Wu, Yi-Long

England: Nature Publishing Group

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