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Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation

Germic, Nina ; Frangez, Ziva ; Yousefi, Shida ; Simon, Hans-Uwe

Cell death and differentiation, 2019-03, Vol.26 (4), p.715-727 [Periódico revisado por pares]

England: Nature Publishing Group

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Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation
Autor: Germic, Nina ; Frangez, Ziva ; Yousefi, Shida ; Simon, Hans-Uwe
Assuntos: Animals ; Antigen presentation ; Antigen Presentation - genetics ; Antigen Presentation - immunology ; Autophagy ; Autophagy - genetics ; Cell Differentiation - genetics ; Cell Differentiation - immunology ; Cytokines - metabolism ; Degranulation ; Dendritic cells ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Histocompatibility Antigens Class I - genetics ; Histocompatibility Antigens Class I - immunology ; Humans ; Immune clearance ; Immune system ; Immunity, Innate ; Immunological tolerance ; Inflammasomes ; Inflammasomes - immunology ; Inflammasomes - metabolism ; Innate immunity ; Leukocytes (eosinophilic) ; Leukocytes (neutrophilic) ; Macrophages ; Macrophages - immunology ; Macrophages - metabolism ; Macrophages - microbiology ; Mast cells ; Monocytes ; Monocytes - immunology ; Monocytes - metabolism ; Natural killer cells ; Phagocytosis ; Phagocytosis - genetics ; Phagocytosis - immunology ; Phagosomes ; Review ; Signal Transduction - immunology
É parte de: Cell death and differentiation, 2019-03, Vol.26 (4), p.715-727
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Autophagy is well equipped functionally to isolate microbial pathogens in autophagosomes and to carry out their clearance by dismemberment in the course of catabolic processes in the lysosome. Clearly, this is a non-metabolic function of autophagy that impacts strongly on the immune system. While in a preceding article on neutrophils, eosinophils, mast cells, and natural killer cells our focus was on the role of autophagy in regulating innate immune cell differentiation, degranulation, phagocytosis and extracellular trap formation, here we discuss monocytes/macrophages and dendritic cells, specifically, the influence of autophagy on functional cellular responses, such as phagocytosis, antigen presentation, cytokine production, control of inflammasome activation, tolerance and the consequences for overall host defense.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Regulation of the innate immune system by autophagy: monocytes, macrophages, dendritic cells and antigen presentation

Germic, Nina ; Frangez, Ziva ; Yousefi, Shida ; Simon, Hans-Uwe

England: Nature Publishing Group

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