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Out of the oil bath and into the oven--microwave-assisted combinatorial chemistry heats up

Blackwell, Helen E

Organic & biomolecular chemistry, 2003-04, Vol.1 (8), p.1251-1255 [Periódico revisado por pares]

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Título:
Out of the oil bath and into the oven--microwave-assisted combinatorial chemistry heats up
Autor: Blackwell, Helen E
É parte de: Organic & biomolecular chemistry, 2003-04, Vol.1 (8), p.1251-1255
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The application of microwave irradiation to expedite solid-phase organic reactions could be the tool that allows combinatorial chemistry to deliver on its promise--providing rapid access to large collections of diverse small molecules. Herein, several different approaches to microwave (MW)-assisted solid-phase reactions and library synthesis are introduced, including the use of solid-supported reagents, multicomponent coupling reactions, solvent-free parallel library synthesis, and spatially addressable library synthesis on planar solid supports. The future impact of MW-assisted organic reactions on solid-phase and combinatorial chemistry could prove to be immense, and methods for further improvement of this strategic combination of technologies are highlighted.
Editor: England
Idioma: Inglês

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