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Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long‐term evaluation

Branco‐de‐Almeida, Luciana S. ; Cruz‐Almeida, Yenisel ; Gonzalez‐Marrero, Yandy ; Kudsi, Rachad ; Oliveira, Izabel C. V. ; Dolia, Bogdan ; Huang, Hong ; Aukhil, Ikramuddin ; Harrison, Peter ; Shaddox, Luciana M.

Journal of clinical periodontology, 2021-02, Vol.48 (2), p.237-248 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

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Título:
Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long‐term evaluation
Autor: Branco‐de‐Almeida, Luciana S. ; Cruz‐Almeida, Yenisel ; Gonzalez‐Marrero, Yandy ; Kudsi, Rachad ; Oliveira, Izabel C. V. ; Dolia, Bogdan ; Huang, Hong ; Aukhil, Ikramuddin ; Harrison, Peter ; Shaddox, Luciana M.
Assuntos: Adolescent ; Adult ; aggressive periodontitis ; Aggressive Periodontitis - therapy ; Amoxicillin ; Amoxicillin - therapeutic use ; Biomarkers ; Bone resorption ; Chemokines ; Child ; Cytokines - analysis ; gingival crevicular fluid ; Gingival Crevicular Fluid - chemistry ; Gum disease ; Humans ; Inflammation ; long‐term effects ; Metronidazole ; Osteoprotegerin ; Patients ; Periodontitis ; therapy ; TRANCE protein ; Young Adult
É parte de: Journal of clinical periodontology, 2021-02, Vol.48 (2), p.237-248
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
LSBA, YCA, and LMS have made substantial contributions to conception and design of the study. LSBA, YGM, and HH have been involved in data collection and analysis. LSBA, YCA, RK, ICVO, BD, and LMS have been involved in data interpretation and drafting the manuscript. IA and PH have critically revised the manuscript. All authors have given final approval of the version to be published.
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Descrição: Aim To evaluate the local immunoinflammatory profiles in localized aggressive periodontitis patients (LAP) before and after periodontal treatment and maintenance. Methods Sixty‐six African‐Americans with LAP (7–21 years old) were included. After periodontal examination, all patients received periodontal treatment with mechanical debridement plus systemic amoxicillin/metronidazole for 7 days. Gingival crevicular fluid was collected from diseased and healthy sites at baseline and 3, 6, 12, and 24 months following treatment. Levels of 16 inflammatory/bone resorption markers were determined using Milliplex®. Univariate and correlation analyses were performed among all parameters/biomarkers. Discriminant analyses (DA) evaluated profile differences between LAP diseased and healthy sites at each time point as compared to the baseline. Results Reductions in the clinical parameters (except for visible plaque) were observed at all time points compared to the baseline. Levels of IL‐12p70, IL‐2, IL‐6, MIP‐1α, RANKL, and OPG were reduced after treatment, and several cytokines/chemokines were correlated with clinical parameters reductions. DA showed that differences in the immunoinflammatory profiles between LAP diseased and healthy sites decreased after periodontal treatment compared to the baseline. Conclusions Periodontal treatment modified the local immunoinflammatory profile of LAP sites in the long term, as suggested by changes in biomarkers from baseline, along with clinical stability of the disease. (Clinicaltrials.gov number, NCT01330719).
Editor: United States: Blackwell Publishing Ltd
Idioma: Inglês

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Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long‐term evaluation

Branco‐de‐Almeida, Luciana S. ; Cruz‐Almeida, Yenisel ; Gonzalez‐Marrero, Yandy ; Kudsi, Rachad ; Oliveira, Izabel C. V. ; Dolia, Bogdan ; Huang, Hong ; Aukhil, Ikramuddin ; Harrison, Peter ; Shaddox, Luciana M.

United States: Blackwell Publishing Ltd

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